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. Author manuscript; available in PMC: 2019 Nov 27.
Published in final edited form as: Environ Mol Mutagen. 2019 Feb 27;60(6):513–533. doi: 10.1002/em.22274

Fig. 8.

Fig. 8.

Left panel: BMD analyses of clastogen compounds represented in cross system plots with BMD100 CIs for in vitro MN vs. BMD50 24 hr γH2AX responses in TK6 cells, with both x and y axes representing Log10 concentration of compounds in μM. The dashed parallel lines are drawn in such a way that encompasses all of the CIs. Dashed square box represents default PROAST output encompassing finite BMD CIs. Right Panel: BMD100 CIs for in vitro MN vs. BMD50 24 hr p53 responses in TK6 cells, with both x and y axes representing Log10 concentration of compounds in μM. Dashed parallel lines encompass most of the BMD CIs. Dashed square box represents default PROAST output encompassing finite BMD CIs. See Table I for compound abbreviations (BMD, Benchmark Dose; CI, confidence interval; MN, micronucleus).