Table 3.

Clinical and Microbiological Outcomes by Baseline Pathogen at Test of Cure (Microbiologic Modified Intent-to-Treat, Post Hoc Pulsed-field Gel Electrophoresis Analysis^a)

Baseline Pathogen	Clinical Cure		Microbiologic Eradication
	ZTI-01, n/N (%)	PIP-TAZ, n/N (%)	ZTI-01, n/N (%)	PIP-TAZ, n/N (%)
Escherichia coli	120/133 (90.2)	120/133 (90.2)	97/133 (72.9)	84/133 (63.2)
Klebsiella pneumoniae	25/27 (92.6)	25/25 (100)	18/27 (66.7)	14/25 (56.0)
Proteus mirabilis	8/9 (88.9)	3/5 (60.0)	8/9 (88.9)	1/5 (20.0)
Enterobacter cloacae species complex	8/9 (88.9)	3/3 (100)	6/9 (66.7)	3/3 (100)
Klebsiella oxytoca	2/3 (66.7)	2/2 (100)	2/3 (66.7)	2/2 (100)
Raoultella ornithinolytica	1/1 (100)	1/1 (100)	1/1 (100)	1/1 (100)
Serratia marcescens	1/1 (100)	1/1 (100)	1/1 (100)	0/1 (0)
Morganella morganii	0/0 (…)	1/1 (100)	0/0 (…)	1/1 (100)
Citrobacter amalonaticus/farmer	1/1 (100)	0/0 (…)	1/1 (100)	0/0 (…)
Pseudomonas aeruginosa	8/8 (100)	9/9 (100)	3/8 (37.5)	4/9 (44.4)
Acinetobacter baumannii-calcoaceticus species complex	2/2 (100)	0/0 (…)	2/2 (100)	0/0 (…)
Enterococcus faecalis	2/3 (66.7)	6/7 (85.7)	1/3 (33.3)	4/7 (57.1)
Staphylococcus aureus	1/1 (100)	0/0 (…)	1/1 (100)	0/0 (…)
Staphylococcus saprophyticus	0/0 (…)	1/1 (100)	0/0 (…)	1/1 (100)

Percentages were calculated using N as the denominator, where N was the number of patients with the specified pathogens. If both a urine and blood sample had the same pathogen at baseline, eradication was defined as the baseline bacterial pathogen was reduced to <10⁴ colony-forming unit/mL on urine culture and was negative on repeat blood culture.

Abbreviations: PIP-TAZ, piperacillin-tazobactam; ZTI-01, fosfomycin for injection.

^aPulsed-field gel electrophoresis was performed to molecularly type all baseline and test-of-cure pathogens (both treatment arms), in order to confirm microbiological eradication/persistence; a total of 20 postbaseline pathogens were identified as unique, unrelated strains compared to baseline.