Table 2.
Number and type of malignancies among individuals of the hereditary breast/ovarian cancer (HBOC) study
| Total | HBOC study | |||||
|---|---|---|---|---|---|---|
| High risk BRCA1+ n (%) |
High risk BRCA2+ n (%) |
High risk BRCA- n (%) |
Low risk n (%) |
|||
| Navarra Cancer Registry | Patients with one or more tumors | |||||
| Single tumor | 506 (85.3%) | 33 (78.6%) | 47 (78.3%) | 303 (86.1%) | 123 (88.5%) | |
| Multiple tumors (a) | 87 (14.7%) | 9 (21.4%) | 13 (21.7%) | 49 (13.9%) | 16 (11.5%) | |
| Total | 593 | 42 | 60 | 352 | 139 | |
| (a) BRCA1/2 vs Low Risk: OR = 2.11 95%CI = 1.04 to 4.33, p-value = 0.038 | ||||||
| Tumors by affected tissue | ||||||
| BREAST | 531 (76.6%) | 30 (55.6%) | 53 (70.7%) | 327 (80.5%) | 120 (76.4%) | |
| OVARY | 55 (7.9%) | 13 (24.1%) | 7 (9.3%) | 27 (6.6%) | 8 (5.1%) | |
| SKIN | 46 (6.6%) | 6 (11.1%) | 4 (5.3%) | 24 (5.9%) | 12 (7.6%) | |
| ENDOMETRIUM | 13 (1.9%) | 1 (1.8%) | 2 (2.7%) | 7 (1.7%) | 3 (1.9%) | |
| PANCREAS | 5 (0.7%) | 2 (3.7%) | 0 | 0 | 3 (1.9%) | |
| COLON | 5 (0.7%) | 0 | 1 (1.3%) | 4 (1%) | 0 | |
| PROSTATE GLAND | 3 (0.4%) | 0 | 2 (2.7%) | 0 | 1 (0.6%) | |
| OTHERS | 35 (5.1%) | 2 (3.7%) | 6 (8%) | 17 (4.2%) | 10 (6.4%) | |
| TOTAL | 693 | 54 | 75 | 406 | 157 | |