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. 2019 Nov 27;21:247. doi: 10.1186/s13075-019-2041-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Osteoarthritis development in SFZ-specific Ctnnb1-knockout mice. a Safranin O staining and OARSI scores of mouse knee joints of Prg4-Cre^ERT2;Ctnnb1^fl/fl and Ctnnb1^fl/fl mice 8 weeks after surgery. Tamoxifen induction was performed at 7 weeks. Each experimental group contained nine biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test). b Immunostaining of β-catenin (Ctnnb1) and Prg4 in sham knee joints of Prg4-Cre^ERT2;Ctnnb1^fl/fl and Ctnnb1^fl/fl mice 8 weeks after surgery. Scale bars, 20 μm. c Safranin O staining and OARSI scores of mouse knee joints of Prg4-Cre^ERT2;Ctnnb1^fl/fl and Ctnnb1^fl/fl mice at 18 months. Tamoxifen induction was performed at 7 weeks. Each experimental group contained six biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test)