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. 2019 Nov 27;21:247. doi: 10.1186/s13075-019-2041-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Regulation of Prg4 expression by Wnt/β-catenin signaling. a–c Protein levels of Ctnbn1 and mRNA levels of Prg4, Acan, and Ctnnb1 in SFZ cells derived from a Prg4-Cre^ERT2;Ctnnb1^fl/fl mice treated with 4-hydroxytamoxifen (4OHT) or vehicle for 48 h, b Prg4-Cre^ERT2;Ctnnb1-ex3^fl/wt mice treated with 4OHT or vehicle for 48 h, or c WT SFZ cells treated with CHIR99021 or vehicle for 48 h. d Immunostaining of Prg4 in mouse femoral heads cultured with CHIR99021 or vehicle for 48 h. Scale bars, 20 μm. All data are expressed as mean ± SD of three biologically independent samples per group. *P < 0.05 versus vehicle (Student’s unpaired two-tailed t test)