Table 2.
Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with their corresponding 95% confidence intervals for each individual immunohistochemical marker for detection of ovarian tumors
| Immuno- histological marker |
n (%) | % (95 Confidence interval: (Lower − Upper)) | ||||
|---|---|---|---|---|---|---|
| Ovary | Colon and appendix | Sensitivity | Specificity | PPV | NPV | |
| CK7 | ||||||
| Positive | 39 (32%) | 9 (12.5%) | 78 (66−89) | 87.5 (80−95) | 81.3 (70 −92) | 85.1 (77−93) |
| Negative | 11 (22%) | 63 (87.5%) | ||||
| CK20 | ||||||
| Positive | 12 (24%) | 63 (87.5%) | 24 (12−38) | 12.5 (5−20) | 16 (8−24) | 19.1 (8−30) |
| Negative | 38 (76%) | 9 (12.5%) | ||||
| CDX2 | ||||||
| Positive | 7 (14%) | 66 (91.7%) | 14 (4−23) | 8.3 (2−15) | 9.6 (3−16) | 12.2 (3−21) |
| Negative | 43 (86%) | 6 (8.3%) | ||||
| PAX8 | ||||||
| Positive | 16 (32%) | 0 (0%) | 32 (19−45) | 100 (100 −100) | 100 (100−100) | 67.9 (59−77) |
| Negative | 34 (68%) | 72 (100%) | ||||
| SATB2 | ||||||
| Positive | 1 (2%) | 38 (52.8%) | 2 (0−6) | 47.2 (36−59) | 2.6 (0−8) | 41 (30−52) |
| Negative | 49 (98%) | 34 (47.2%) | ||||
The sensitivity, specificity, PPV, and NPV was calculated for the primary mucinous ovarian neoplasms. Immunostains were considered “positive” if > 5% of the tumor cells expressed the marker, and “negative” if < 5% of the tumor cells expressed the marker