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. 2019 Oct 25;18(6):5041–5051. doi: 10.3892/etm.2019.8139

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Copyright: © Bostan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — ERK1/2 in the activation of p53 in HNSCC cells treated with CisPt and/or CRM. (A) The total and phospho-p53 protein expression (ng/mg total protein lysate) in FaDu, PE/CA-PJ49 cells treated with CisPt and/or CRM. a, CisPt vs. Control; b, CRM vs. Control; c, CisPt+CRM vs. Control. (B) Inhibitory effect of PD98059 on the total and phospho-p53 expression. The experiments were performed in triplicates. Results are expressed as mean values of three determinations ± standard deviation (SD). [PD98059 effect (%) = (protein expression+PD98059/protein expression-PD98059) ×100]. a, CisPt vs. Control; b, CRM vs. Control; c, CisPt +CRM vs. Control.