Figure 2.

Patterns of hair cell loss in the 23 human temporal bones analyzed in the present study. A, Age-related loss of hair cells, showing mean survival in each case, averaged over the 11 half-octave samples within the audiometric frequency range (0.25–8.0 kHz inclusive). OHC values represent the average of all three rows. Best-fit straight lines are shown in red, as indicated in the key, along with correlation coefficients and p values. B, C, Frequency pattern of hair cell loss, showing mean survival (±SEMs) of IHCs (B) and OHCs (C) at each of the 14 half-octave cochlear frequency locations sampled. Case patients are arbitrarily divided into three age groups, as illustrated in A. The significance of the intergroup differences is indicated by asterisks: *p < 0.05; **p < 0.005; ***p < 0.0005; ****p < 0.0001; or n.s. (not significant).