Table 2.

The expression of NLRC5 in various species influenced by inflammation.

Species	Tissues/Cells	Upregulated/Downregulated	Pathways	Author, Year
Chicken	Macrophages	Upregulated	IFNA and IFNB	Lian et al., 2012
Mice	Peritoneal macrophages	Upregulated	NF-κB/IFN-1	Tong et al., 2012
Mice	RAW264.7	Upregulated	JAK2/STAT3	Li et al., 2014
Chicken	Spleen	Upregulated	NF-κB	Chang et al., 2015
Human	LX-2 cells	Upregulated	NF-κB/Smad3	Xu et al., 2015
Human	HCC tissues and cells	Upregulated	AKT/VEGF-A	He et al., 2016
Human	Cervical cells	Upregulated	MiR/NF-κB	Li et al., 2016a; Li et al., 2016b
Mice	HSC cells	Upregulated	NF-κB	Liu et al., 2016
Human	Keloid fibroblasts	Upregulated	TGF-β1/Smad	Ma et al., 2016
Human	HCC tissues and cells	Upregulated	Wnt/β-catenin	Peng et al., 2016
Fish	Atlantic Salmon	Upregulated or Downregulated	NLRC5 inflammasome	Pontigo et al., 2016
Chicken	Embryo fibroblasts	Downregulated	MHC-I	Qiu et al., 2016
Mice	Liver tissues and HSC	Upregulated	NF-κB	Xu et al., 2016
Rat	FLSs	Upregulated	NF-κB	Liu et al., 2017b
Fish	Zebrafish	Upregulated	IFN-1	Wu et al., 2017
Fish	Rainbow trout	Upregulated or Downregulated	unknown	Alvarez et al., 2017
Mice	Cardiac muscle cells	Downregulated	TLR4/NF-κB	Ma and Xie, 2017
Rat	Cardiac fibroblasts	Upregulated	TGF-β1/Smad3	Zhou et al., 2017
Human	HK-2	Upregulated	PI3K/AKT	Han et al., 2018
Mice	Hepatocyte	Upregulated	Noncoding RNA	Wang et al.,2018
Human	Renal biopsy samples	Upregulated	TGF-β1/Smad	Wang et al., 2018
Human	Blood samples	Downregulated	Methylation	Zeng et al., 2018