Table 2.
The results of GO enrichment analysis.
| ID | Description | Gene ratio |
|---|---|---|
| GO: 0001968 | Fibronectin binding | 4/122 |
| GO: 0005201 | Extracellular matrix structural constituent | 7/122 |
| GO: 0019888 | Protein phosphatase regulator activity | 5/122 |
| GO: 0046332 | SMAD binding | 5/122 |
| GO: 0019838 | Growth factor binding | 6/122 |
| GO: 0050431 | Transforming growth factor beta binding | 3/122 |
| GO: 0019208 | Phosphatase regulator activity | 5/122 |
| GO: 0001227 | Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | 7/122 |
| GO: 0001221 | Transcription cofactor binding | 3/122 |
| GO: 0004864 | Protein phosphatase inhibitor activity | 3/122 |
| GO: 0019212 | Phosphatase inhibitor activity | 3/122 |
| GO: 0072542 | Protein phosphatase activator activity | 2/122 |
| GO: 0048185 | Activin binding | 2/122 |
| GO: 0004857 | Enzyme inhibitor activity | 8/122 |
| GO: 0004674 | Protein serine/threonine kinase activity | 9/122 |
| GO: 0005024 | Transforming growth factor beta-activated receptor activity | 2/122 |
| GO: 0030169 | Low-density lipoprotein particle binding | 2/122 |
| GO: 0070888 | E-box binding | 3/122 |
| GO: 0019211 | Phosphatase activator activity | 2/122 |
| GO: 0004675 | Transmembrane receptor protein serine/threonine kinase activity | 2/122 |
| GO: 0003779 | Actin binding | 8/122 |
| GO: 0001223 | Transcription coactivator binding | 2/122 |
| GO: 0030742 | GTP-dependent protein binding | 2/122 |
| GO: 0019955 | Cytokine binding | 4/122 |
| GO: 0005518 | Collagen binding | 3/122 |
| GO: 0017022 | Myosin binding | 3/122 |
| GO: 0019903 | Protein phosphatase binding | 4/122 |
| GO: 0005520 | Insulin-like growth factor binding | 2/122 |
| GO: 0071813 | Lipoprotein particle binding | 2/122 |
| GO: 0071814 | Protein-lipid complex binding | 2/122 |
| GO: 0030332 | Cyclin binding | 2/122 |
| GO: 0035035 | Histone acetyltransferase binding | 2/122 |
| GO: 0051721 | Protein phosphatase 2A binding | 2/122 |
| GO: 0019199 | Transmembrane receptor protein kinase activity | 3/122 |
| GO: 0003713 | Transcription coactivator activity | 6/122 |
| GO: 1901682 | Sulfur compound transmembrane transporter activity | 2/122 |
| GO: 0030020 | Extracellular matrix structural constituent conferring tensile strength | 2/122 |
| GO: 0043531 | ADP binding | 2/122 |
| GO: 0001078 | Transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | 4/122 |
| GO: 0019902 | Phosphatase binding | 4/122 |
| GO: 0000982 | Transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | 7/122 |
| GO: 0019887 | l kinase regulator activity | 4/122 |
| GO: 0001228 | Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | 7/122 |
| GO: 0016706 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | 2/122 |
| GO: 0051018 | Protein kinase A binding | 2/122 |
| GO: 0045309 | Protein phosphorylated amino acid binding | 2/122 |
| GO: 0005160 | Transforming growth factor beta receptor binding | 2/122 |
| GO: 0031625 | Ubiquitin protein ligase binding | 5/122 |
| GO: 0031490 | Chromatin DNA binding | 3/122 |
| ID | Bg ratio | p Value | p Adjust | q Value | Gene ID | Count |
|---|---|---|---|---|---|---|
| GO: 0001968 | 27/17632 | 3.39E-05 | 0.012118429 | 0.011010275 | CTGF/FSTL3/THBS1/IGFBP5 | 4 |
| GO: 0005201 | 155/17632 | 0.00010192 | 0.018243653 | 0.016575386 | FBN2/MUC17/LAMC1/THBS1/TGFBI/COL1A1/COL5A2 | 7 |
| GO: 0019888 | 80/17632 | 0.000232027 | 0.020766389 | 0.018867433 | PHACTR2/PPP2R5E/PPP1R9B/PPP1R10/CALM2 | 5 |
| GO: 0046332 | 80/17632 | 0.000232027 | 0.020766389 | 0.018867433 | PRDM16/MYOCD/TGFBR1/COL5A2/TGFBR2 | 5 |
| GO: 0019838 | 137/17632 | 0.000381094 | 0.025089597 | 0.022795311 | CTGF/THBS1/IGFBP5/TGFBR1/COL1A1/TGFBR2 | 6 |
| GO: 0050431 | 22/17632 | 0.000452113 | 0.025089597 | 0.022795311 | THBS1/TGFBR1/TGFBR2 | 3 |
| GO: 0019208 | 94/17632 | 0.000490579 | 0.025089597 | 0.022795311 | PHACTR2/PPP2R5E/PPP1R9B/PPP1R10/CALM2 | 5 |
| GO: 0001227 | 267/17632 | 0.002578004 | 0.098990696 | 0.089938622 | FOXO1/MYC/ZEB1/HEYL/PRDM1/PRRX1/FOXO3 | 7 |
| GO: 0001221 | 41/17632 | 0.002844169 | 0.098990696 | 0.089938622 | CCNT2/FOXO1/FOXO3 | 3 |
| GO: 0004864 | 41/17632 | 0.002844169 | 0.098990696 | 0.089938622 | PHACTR2/PPP1R9B/PPP1R10 | 3 |
| GO: 0019212 | 44/17632 | 0.003480829 | 0.098990696 | 0.089938622 | PHACTR2/PPP1R9B/PPP1R10 | 3 |
| GO: 0072542 | 13/17632 | 0.003523642 | 0.098990696 | 0.089938622 | PPP2R5E/CALM2 | 2 |
| GO: 0048185 | 14/17632 | 0.004092371 | 0.098990696 | 0.089938622 | FSTL3/TGFBR1 | 2 |
| GO: 0004857 | 371/17632 | 0.004286672 | 0.098990696 | 0.089938622 | PHACTR2/TXNIP/SOCS3/PRKAR1A/PPP1R9B/PPP1R10/SERPINH1/SERPINE1 | 8 |
| GO: 0004674 | 455/17632 | 0.004378555 | 0.098990696 | 0.089938622 | TRPM7/CCNT2/MKNK2/PDIK1L/PRKAA1/CDK6/UHMK1/TGFBR1/TGFBR2 | 9 |
| GO: 0005024 | 15/17632 | 0.004700676 | 0.098990696 | 0.089938622 | TGFBR1/TGFBR2 | 2 |
| GO: 0030169 | 15/17632 | 0.004700676 | 0.098990696 | 0.089938622 | LDLR/THBS1 | 2 |
| GO: 0070888 | 50/17632 | 0.004998838 | 0.099421342 | 0.090329887 | CLOCK/MYC/ZEB1 | 3 |
| GO: 0019211 | 16/17632 | 0.005347991 | 0.100767416 | 0.091552872 | PPP2R5E/CALM2 | 2 |
| GO: 0004675 | 17/17632 | 0.006033758 | 0.108004271 | 0.098127961 | TGFBR1/TGFBR2 | 2 |
| GO: 0003779 | 421/17632 | 0.00895487 | 0.148900927 | 0.135284877 | MYO6/WASF2/TRPM7/PHACTR2/TNS1/MAP1B/CXCR4/PPP1R9B | 8 |
| GO: 0001223 | 21/17632 | 0.009150336 | 0.148900927 | 0.135284877 | CCNT2/FOXO1 | 2 |
| GO: 0030742 | 22/17632 | 0.010020159 | 0.155965948 | 0.141703845 | RAPGEF6/RAB34 | 2 |
| GO: 0019955 | 125/17632 | 0.011123838 | 0.160730102 | 0.146032348 | THBS1/CXCR4/TGFBR1/TGFBR2 | 4 |
| GO: 0005518 | 67/17632 | 0.011224169 | 0.160730102 | 0.146032348 | THBS1/TGFBI/SERPINH1 | 3 |
| GO: 0017022 | 68/17632 | 0.011683934 | 0.160878783 | 0.146167433 | TRPM7/RAB27A/CXCR4 | 3 |
| GO: 0019903 | 133/17632 | 0.013712012 | 0.181811121 | 0.16518564 | FOXO1/SIRPA/STRN4/PPP1R9B | 4 |
| GO: 0005520 | 28/17632 | 0.015960482 | 0.185140606 | 0.168210665 | CTGF/IGFBP5 | 2 |
| GO: 0071813 | 28/17632 | 0.015960482 | 0.185140606 | 0.168210665 | LDLR/THBS1 | 2 |
| GO: 0071814 | 28/17632 | 0.015960482 | 0.185140606 | 0.168210665 | LDLR/THBS1 | 2 |
| GO: 0030332 | 29/17632 | 0.017066033 | 0.185140606 | 0.168210665 | FBXW7/CDK6 | 2 |
| GO: 0035035 | 29/17632 | 0.017066033 | 0.185140606 | 0.168210665 | MYOCD/CITED2 | 2 |
| GO: 0051721 | 29/17632 | 0.017066033 | 0.185140606 | 0.168210665 | FOXO1/STRN4 | 2 |
| GO: 0019199 | 81/17632 | 0.018648344 | 0.196356092 | 0.178400566 | EPHA4/TGFBR1/TGFBR2 | 3 |
| GO: 0003713 | 321/17632 | 0.024230576 | 0.247844173 | 0.225180387 | PRDM16/RARG/ZEB1/PRRX1/MYOCD/CITED2 | 6 |
| GO: 1901682 | 36/17632 | 0.025665148 | 0.255225634 | 0.231886859 | SLC35B3/SLC19A3 | 2 |
| GO: 0030020 | 37/17632 | 0.027010862 | 0.261348336 | 0.237449679 | COL1A1/COL5A2 | 2 |
| GO: 0043531 | 39/17632 | 0.02978569 | 0.274678286 | 0.249560689 | MYO6/APAF1 | 2 |
| GO: 0001078 | 169/17632 | 0.029923053 | 0.274678286 | 0.249560689 | FOXO1/HEYL/PRDM1/PRRX1 | 4 |
| GO: 0019902 | 178/17632 | 0.035210199 | 0.304397033 | 0.276561844 | FOXO1/SIRPA/STRN4/PPP1R9B | 4 |
| GO: 0000982 | 447/17632 | 0.03582466 | 0.304397033 | 0.276561844 | KLF5/FOXO1/MYC/HEYL/PRDM1/PRRX1/MYOCD | 7 |
| GO: 0019887 | 180/17632 | 0.036454143 | 0.304397033 | 0.276561844 | CCNT2/SOCS3/PRKAR1A/CALM2 | 4 |
| GO: 0001228 | 449/17632 | 0.036561655 | 0.304397033 | 0.276561844 | KLF5/CLOCK/MYC/HEYL/VEZF1/MYOCD/FOXO3 | 7 |
| GO: 0016706 | 47/17632 | 0.041933365 | 0.341185106 | 0.30998588 | TET3/P4HA2 | 2 |
| GO: 0051018 | 48/17632 | 0.043562833 | 0.346566539 | 0.314875215 | WASF2/PRKAR1A | 2 |
| GO: 0045309 | 49/17632 | 0.045215614 | 0.351895431 | 0.319716813 | FBXW7/SOCS3 | 2 |
| GO: 0005160 | 51/17632 | 0.04858954 | 0.352879061 | 0.320610497 | TGFBR1/TGFBR2 | 2 |
| GO: 0031625 | 286/17632 | 0.048696742 | 0.352879061 | 0.320610497 | FOXO1/FBXW7/TXNIP/CXCR4/PRKAR1A | 5 |
| GO: 0031490 | 119/17632 | 0.049642361 | 0.352879061 | 0.320610497 | CLOCK/PRDM1/FOXO3 | 3 |