Table 3.

The results of KEGG pathway analysis.

ID	Description	Gene ratio	Bg ratio	p Value
hsa04218	Cellular senescence	10/57	160/7466	2.80E-07
hsa04115	p53 signaling pathway	6/57	72/7466	1.60E-05
hsa04910	Insulin signaling pathway	7/57	137/7466	7.39E-05
hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/57	99/7466	9.81E-05
hsa05220	Chronic myeloid leukemia	5/57	76/7466	0.000265202
hsa04068	FoxO signaling pathway	6/57	132/7466	0.000472257
hsa04211	Longevity regulating pathway	6/57	89/7466	0.000552582
hsa04371	Apelin signaling pathway	6/57	137/7466	0.000575675
hsa05165	Human papillomavirus infection	9/57	330/7466	0.000794412
hsa04390	Hippo signaling pathway	6/57	154/7466	0.001064365
hsa05160	Hepatitis C	6/57	155/7466	0.001100757
hsa04213	Longevity regulating pathway - multiple species	6/57	62/7466	0.00122559
hsa04151	PI3K-Akt signaling pathway	9/57	354/7466	0.0013066
hsa04137	Mitophagy – animal	4/57	65/7466	0.001462455
hsa04520	Adherens junction	4/57	72/7466	0.002136126
hsa05212	Pancreatic cancer	4/57	75/7466	0.002481334
hsa05202	Transcriptional misregulation in cancer	6/57	186/7466	0.002786785
hsa05219	Bladder cancer	3/57	41/7466	0.003662102
hsa04350	TGF-beta signaling pathway	4/57	85/7466	0.003907022
hsa05210	Colorectal cancer	4/57	86/7466	0.004074595
hsa04015	Rap1 signaling pathway	6/57	206/7466	0.004611998
hsa05161	Hepatitis B	5/57	144/7466	0.004659537
hsa05222	Small cell lung cancer	4/57	93/7466	0.005385847
hsa05163	Human cytomegalovirus infection	6/57	225/7466	0.007051458

ID	p. Adjust	q Value	Gene ID	Count
hsa04218	4.68E-05	3.51E-05	TRPM7/FOXO1/MYC/CDK6/KRAS/TGFBR1/TGFBR2/SERPINE1/CALM2/FOXO3	10
hsa04115	0.001338182	0.001003742	PERP/APAF1/CDK6/SESN2/THBS1/SERPINE1	6
hsa04910	0.004095217	0.003071736	FOXO1/MKNK2/PRKAA1/KRAS/SOCS3/PRKAR1A/CALM2	7
hsa04933	0.004095217	0.003071736	FOXO1/KRAS/TGFBR1/COL1A1/TGFBR2/SERPINE1	6
hsa05220	0.008857732	0.006643997	MYC/CDK6/KRAS/TGFBR1/TGFBR2	5
hsa04068	0.012017218	0.00901386	FOXO1/PRKAA1/KRAS/TGFBR1/TGFBR2/FOXO3	6
hsa04211	0.012017218	0.00901386	FOXO1/PRKAA1/KRAS/SESN2/FOXO3	5
hsa04371	0.012017218	0.00901386	PRKAA1/KRAS/CTGF/TGFBR1/SERPINE1/CALM2	6
hsa05165	0.014740748	0.011056723	FOXO1/PARD6B/CDK6/KRAS/HEYL/LAMC1/THBS1/COL1A1/PPP2R5E	9
hsa04390	0.016711491	0.012534935	PARD6B/MYC/CTGF/TGFBR1/TGFBR2/SERPINE1	6
hsa05160	0.016711491	0.012534935	LDLR/APAF1/MYC/CDK6/KRAS/SOCS3	6
hsa04213	0.016784782	0.012589909	FOXO1/PRKAA1/KRAS/FOXO3	4
hsa04151	0.016784782	0.012589909	PRKAA1/MYC/CDK6/KRAS/LAMC1/THBS1/COL1A1/PPP2R5E/FOXO3	9
hsa04137	0.017444997	0.013085122	OPTN/KRAS/CITED2/FOXO3	4
hsa04520	0.023782202	0.017838526	WASF2/CTNND1/TGFBR1/TGFBR2	4
hsa05212	0.025898925	0.019426234	CDK6/KRAS/TGFBR1/TGFBR2	4
hsa05202	0.027376065	0.020534206	CCNT2/FOXO1/MYC/ZEB1/AFF1/TGFBR2	6
hsa05219	0.033976167	0.025484802	MYC/KRAS/THBS1	3
hsa04350	0.03402287	0.025519833	MYC/THBS1/TGFBR1/TGFBR2	4
hsa05210	0.03402287	0.025519833	MYC/KRAS/TGFBR1/TGFBR2	4
hsa04015	0.03537012	0.026530377	PARD6B/RAPGEF6/CTNND1/KRAS/THBS1/CALM2	6
hsa05161	0.03537012	0.026530377	APAF1/MYC/CDK6/KRAS/TGFBR1	5
hsa05222	0.03910593	0.029332528	APAF1/MYC/CDK6/LAMC1	4
hsa05163	0.049066392	0.03680366	B2M/MYC/CDK6/KRAS/CXCR4/CALM2	6