Table 4.
The rank of hub genes via various of situations.
| Node name | MCC | DMNC | MNC | Degree | EPC | Bottle neck | Ec centricity | Closeness | Radiality | Betweenness | Stress | Clustering coefficient |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MYC | 609 | 0.24794 | 25 | 30 | 36.302 | 49 | 0.22965 | 50.91667 | 5.72361 | 2930.436 | 6766 | 0.13563 |
| CTGF | 401 | 0.37042 | 13 | 14 | 35.37 | 8 | 0.18372 | 40.61667 | 5.33497 | 676.2413 | 2134 | 0.31868 |
| TGFBR2 | 396 | 0.49882 | 10 | 10 | 34.088 | 3 | 0.18372 | 38.03333 | 5.25253 | 183.2476 | 1158 | 0.55556 |
| TGFBR1 | 396 | 0.49882 | 10 | 10 | 33.892 | 1 | 0.18372 | 38.03333 | 5.25253 | 183.2476 | 1158 | 0.55556 |
| SERPINE1 | 370 | 0.5012 | 9 | 11 | 34.56 | 8 | 0.18372 | 39.45 | 5.34675 | 868.6996 | 2280 | 0.38182 |
| KRAS | 322 | 0.36053 | 15 | 17 | 36.072 | 16 | 0.18372 | 42.76667 | 5.39386 | 828.0731 | 2704 | 0.26471 |
| ZEB1 | 318 | 0.45368 | 12 | 12 | 35.42 | 8 | 0.18372 | 39.2 | 5.28787 | 194.055 | 870 | 0.4697 |
| THBS1 | 259 | 0.41901 | 10 | 11 | 33.93 | 6 | 0.18372 | 38.61667 | 5.26431 | 402.2999 | 1202 | 0.38182 |
| CDK6 | 250 | 0.47733 | 9 | 11 | 33.692 | 3 | 0.18372 | 38.26667 | 5.20543 | 428.6176 | 1188 | 0.36364 |
| TNS1 | 240 | 0.62199 | 7 | 7 | 32.135 | 1 | 0.18372 | 35.18333 | 5.07588 | 8.55088 | 56 | 0.80952 |
| COL1A1 | 142 | 0.32239 | 11 | 11 | 33.115 | 4 | 0.1531 | 34.35 | 4.85212 | 350.8601 | 1722 | 0.34545 |
| FOXO1 | 134 | 0.31924 | 10 | 10 | 33.841 | 4 | 0.18372 | 37.95 | 5.24076 | 203.7761 | 800 | 0.35556 |
| FOXO3 | 131 | 0.4082 | 8 | 11 | 32.054 | 2 | 0.18372 | 36.85 | 5.09943 | 398.0874 | 1268 | 0.25455 |
| DICER1 | 121 | 0.64826 | 5 | 6 | 29.184 | 2 | 0.18372 | 34.18333 | 5.02877 | 157.1734 | 434 | 0.66667 |
| CXCR4 | 58 | 0.37904 | 8 | 8 | 32.284 | 11 | 0.18372 | 36.86667 | 5.2172 | 178.6964 | 600 | 0.46429 |
| MUC1 | 52 | 0.47549 | 6 | 8 | 30.378 | 5 | 0.18372 | 36.43333 | 5.1701 | 366.1695 | 864 | 0.39286 |
| IGFBP5 | 32 | 0.36588 | 7 | 7 | 28.18 | 1 | 0.1531 | 32.31667 | 4.82856 | 193.0638 | 622 | 0.47619 |
| LAMC1 | 28 | 0.38039 | 6 | 6 | 26.728 | 1 | 0.1531 | 30.46667 | 4.67546 | 88.60129 | 278 | 0.53333 |
| CALU | 27 | 0.56839 | 4 | 7 | 27.046 | 7 | 0.1531 | 32.88333 | 4.87567 | 368.5913 | 1006 | 0.33333 |
| STC2 | 25 | 0.56839 | 4 | 5 | 21.431 | 2 | 0.13123 | 27.22619 | 4.34571 | 112.2128 | 258 | 0.6 |
| FSTL3 | 24 | 0.56839 | 4 | 4 | 21.367 | 1 | 0.13123 | 26.34286 | 4.28682 | 0 | 0 | 1 |
| SOCS3 | 21 | 0.38039 | 6 | 7 | 29.643 | 3 | 0.18372 | 34.51667 | 5.02877 | 250.4977 | 792 | 0.38095 |
| FBXW7 | 20 | 0.38039 | 6 | 6 | 29.119 | 1 | 0.18372 | 34.18333 | 5.02877 | 77.23846 | 304 | 0.53333 |
| FBN2 | 8 | 0.37893 | 4 | 4 | 23.641 | 2 | 0.1531 | 27.75 | 4.48703 | 26.03518 | 280 | 0.66667 |
| KLF5 | 7 | 0.46346 | 3 | 4 | 24.062 | 2 | 0.18372 | 32.68333 | 4.96989 | 59.30048 | 238 | 0.5 |
| PRKAA1 | 7 | 0.30898 | 3 | 6 | 25.204 | 1 | 0.1531 | 30.03333 | 4.6048 | 61.26671 | 174 | 0.13333 |
| PRRX1 | 6 | 0.46346 | 3 | 3 | 23.368 | 1 | 0.1531 | 27.36667 | 4.48703 | 0 | 0 | 1 |
| TGFBI | 6 | 0.46346 | 3 | 3 | 23.103 | 1 | 0.1531 | 28.15 | 4.53414 | 0 | 0 | 1 |
| COL5A2 | 6 | 0.2842 | 4 | 4 | 19.627 | 1 | 0.13123 | 24.70952 | 3.9924 | 5 | 10 | 0.5 |
| PPP2R5E | 5 | 0 | 1 | 5 | 19.69 | 3 | 0.1531 | 30.61667 | 4.69902 | 302.8195 | 790 | 0 |
| CASP2 | 5 | 0.30898 | 3 | 4 | 20.746 | 2 | 0.18372 | 31.93333 | 4.88745 | 143.4932 | 330 | 0.33333 |
| SERPINH1 | 5 | 0.30898 | 3 | 4 | 20.532 | 2 | 0.1531 | 28.4 | 4.52236 | 171.9268 | 490 | 0.33333 |
| TXNIP | 4 | 0.30898 | 3 | 3 | 20.773 | 2 | 0.18372 | 32.1 | 4.93456 | 12.23252 | 76 | 0.66667 |
| PRDM1 | 4 | 0.30898 | 3 | 3 | 22.727 | 1 | 0.18372 | 31.1 | 4.85212 | 0.68182 | 4 | 0.66667 |
| B2M | 4 | 0.30779 | 2 | 4 | 18.355 | 7 | 0.18372 | 32.53333 | 4.96989 | 716.2094 | 1514 | 0.33333 |
| CTNND1 | 4 | 0.30779 | 2 | 4 | 18.921 | 5 | 0.18372 | 32.68333 | 4.95811 | 480.2316 | 832 | 0.16667 |
| APAF1 | 4 | 0.30898 | 3 | 3 | 20.821 | 1 | 0.18372 | 31.76667 | 4.89922 | 4.66667 | 16 | 0.66667 |
| SIN3B | 3 | 0.30779 | 2 | 3 | 18.56 | 2 | 0.18372 | 32.26667 | 4.95811 | 154 | 238 | 0.33333 |
| FNBP1 | 3 | 0 | 1 | 3 | 4.766 | 3 | 0.1531 | 22.36667 | 3.81574 | 277.7906 | 550 | 0 |
| LDLR | 3 | 0 | 1 | 3 | 11.833 | 5 | 0.18372 | 27.81667 | 4.58125 | 537.7906 | 1026 | 0 |
| FRK | 3 | 0.30779 | 2 | 3 | 7.811 | 2 | 0.18372 | 24.4 | 4.15727 | 154 | 298 | 0.33333 |
| MYO6 | 3 | 0 | 1 | 3 | 8.446 | 3 | 0.1531 | 24.88333 | 4.19261 | 218.1825 | 368 | 0 |
| SESN2 | 3 | 0.30779 | 2 | 3 | 21.783 | 1 | 0.18372 | 32.85 | 5.01699 | 34.11001 | 178 | 0.33333 |
| RAB27A | 3 | 0.30779 | 2 | 3 | 8.435 | 4 | 0.18372 | 24.86667 | 4.20438 | 326.2094 | 692 | 0.33333 |
| RAB34 | 3 | 0 | 1 | 3 | 4.339 | 3 | 0.1531 | 20.68333 | 3.43888 | 210.7381 | 444 | 0 |
| CLOCK | 3 | 0 | 1 | 3 | 16.66 | 1 | 0.1531 | 28.1 | 4.58125 | 65.63025 | 158 | 0 |
| PERP | 2 | 0 | 1 | 2 | 12.381 | 2 | 0.18372 | 30.6 | 4.84034 | 43.91725 | 162 | 0 |
| CALM2 | 2 | 0 | 1 | 2 | 8.433 | 1 | 0.13123 | 22.04286 | 3.76863 | 29.95094 | 44 | 0 |
| RARG | 2 | 0 | 1 | 2 | 14.151 | 2 | 0.18372 | 30.93333 | 4.87567 | 28.30952 | 88 | 0 |
| WASF2 | 2 | 0 | 1 | 2 | 3.067 | 1 | 0.13123 | 18.80952 | 3.06202 | 38.52872 | 68 | 0 |
| MBNL1 | 2 | 0 | 1 | 2 | 10.944 | 1 | 0.1531 | 24.3 | 4.15727 | 10.72727 | 40 | 0 |
| MYOCD | 2 | 0 | 1 | 2 | 14.687 | 1 | 0.1531 | 25.3 | 4.23971 | 2.05556 | 8 | 0 |
| FAM46A | 2 | 0 | 1 | 2 | 1.568 | 3 | 0.03488 | 2 | 0.12209 | 2 | 2 | 0 |
| PRKAR1A | 2 | 0 | 1 | 2 | 16.389 | 1 | 0.1531 | 27.86667 | 4.53414 | 4.43252 | 46 | 0 |
| CITED2 | 2 | 0 | 1 | 2 | 12.229 | 1 | 0.1531 | 25.05 | 4.21616 | 3.06667 | 8 | 0 |
| PPP1R10 | 2 | 0 | 1 | 2 | 11.151 | 1 | 0.1531 | 24.55 | 4.18083 | 27.70586 | 98 | 0 |
| PPP1R9B | 2 | 0 | 1 | 2 | 8.77 | 1 | 0.13123 | 22.55952 | 3.8393 | 7 | 8 | 0 |
| PTBP2 | 2 | 0 | 1 | 2 | 8.932 | 1 | 0.1531 | 23.3 | 4.01595 | 3.55385 | 8 | 0 |
| P4HA2 | 2 | 0.30779 | 2 | 2 | 13.847 | 1 | 0.13123 | 23.54286 | 3.95707 | 0 | 0 | 1 |
| GALNT6 | 2 | 0.30779 | 2 | 2 | 11.642 | 1 | 0.1531 | 24.96667 | 4.27504 | 0 | 0 | 1 |
| FBXL7 | 2 | 0.30779 | 2 | 2 | 15.652 | 1 | 0.1531 | 24.63333 | 4.19261 | 0 | 0 | 1 |
| MUC17 | 2 | 0.30779 | 2 | 2 | 11.691 | 1 | 0.1531 | 24.96667 | 4.27504 | 0 | 0 | 1 |
| RER1 | 1 | 0 | 1 | 1 | 8.885 | 1 | 0.13123 | 22.69286 | 3.96884 | 0 | 0 | 0 |
| AMOTL1 | 1 | 0 | 1 | 1 | 12.027 | 1 | 0.1531 | 26.06667 | 4.42815 | 0 | 0 | 0 |
| SPAG9 | 1 | 0 | 1 | 1 | 10.867 | 1 | 0.18372 | 29.93333 | 4.81679 | 0 | 0 | 0 |
| SIRPA | 1 | 0 | 1 | 1 | 10.606 | 1 | 0.1531 | 25.31667 | 4.35748 | 0 | 0 | 0 |
| AHCYL2 | 1 | 0 | 1 | 1 | 1.322 | 1 | 0.02326 | 1 | 0.06977 | 0 | 0 | 0 |
| HIGD1A | 1 | 0 | 1 | 1 | 1.322 | 1 | 0.02326 | 1 | 0.06977 | 0 | 0 | 0 |
| PHACTR2 | 1 | 0 | 1 | 1 | 1.374 | 1 | 0.01744 | 1.5 | 0.10465 | 0 | 0 | 0 |
| MSL2 | 1 | 0 | 1 | 1 | 2.175 | 1 | 0.13123 | 17.24286 | 2.90891 | 0 | 0 | 0 |
| AFF1 | 1 | 0 | 1 | 1 | 10.166 | 1 | 0.1531 | 25.1 | 4.2986 | 0 | 0 | 0 |
| TMF1 | 1 | 0 | 1 | 1 | 2.402 | 1 | 0.13123 | 16.14524 | 2.53205 | 0 | 0 | 0 |
| C4orf19 | 1 | 0 | 1 | 1 | 6.234 | 1 | 0.1531 | 22.86667 | 4.05128 | 0 | 0 | 0 |
| STRN4 | 1 | 0 | 1 | 1 | 6.291 | 1 | 0.13123 | 21.64286 | 3.79219 | 0 | 0 | 0 |
| BBX | 1 | 0 | 1 | 1 | 6.08 | 1 | 0.1531 | 22.75 | 4.05128 | 0 | 0 | 0 |
| SPATA5 | 1 | 0 | 1 | 1 | 1.289 | 1 | 0.02326 | 1 | 0.06977 | 0 | 0 | 0 |
| UBE4B | 1 | 0 | 1 | 1 | 1.289 | 1 | 0.02326 | 1 | 0.06977 | 0 | 0 | 0 |
| PRDM16 | 1 | 0 | 1 | 1 | 11.749 | 1 | 0.18372 | 29.93333 | 4.81679 | 0 | 0 | 0 |
| C10orf10 | 1 | 0 | 1 | 1 | 9.952 | 1 | 0.1531 | 24.38333 | 4.19261 | 0 | 0 | 0 |
| OPTN | 1 | 0 | 1 | 1 | 3.585 | 1 | 0.13123 | 18.7619 | 3.28578 | 0 | 0 | 0 |
| TSPAN12 | 1 | 0 | 1 | 1 | 4.562 | 1 | 0.1531 | 20.43333 | 3.67442 | 0 | 0 | 0 |
| FNDC3B | 1 | 0 | 1 | 1 | 1.358 | 1 | 0.01744 | 1.5 | 0.10465 | 0 | 0 | 0 |
| EDEM3 | 1 | 0 | 1 | 1 | 7.224 | 1 | 0.13123 | 20.55952 | 3.61553 | 0 | 0 | 0 |
| CCNT2 | 1 | 0 | 1 | 1 | 10.511 | 1 | 0.1531 | 25.1 | 4.2986 | 0 | 0 | 0 |
| NHLRC3 | 1 | 0 | 1 | 1 | 3.536 | 1 | 0.1531 | 18.5 | 3.25045 | 0 | 0 | 0 |
| NFYA | 1 | 0 | 1 | 1 | 11.172 | 1 | 0.18372 | 29.93333 | 4.81679 | 0 | 0 | 0 |