Figure 6. Pharmacologic enhancement of γ2 subunit containing GABA_A receptor function rescued anxiety-like behavior in Gabrg2 deficient epilepsy mice.

A, B. Either vehicle (normal saline) or diazepam (0.3 mg/kg ip, DZP) was administered 30 min before testing. In the elevated zero maze (EZM), the time spent in open arms (A) and the total number of entry into open arms (B) were measured.

C, D. In OF test, the total distance travelled (C) and the ratio of time in center vs periphery (D) were measured.

E, F. In light/dark choice, the time spent in the lit area and the number of light/dark transitions were measured.

G. In three-chamber test, the time spent with novel mouse was measured. (*p < 0.05; **p < 0.01 vs wt, § p<0.05 vs het with vehicle. n = 8 mice for het = vehicle and n = 9 mice for other groups. Data were presented as mean as mean ± S.E.M).