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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Circulation. 2019 Oct 1;140(14):1205–1216. doi: 10.1161/CIRCULATIONAHA.119.040551

Figure 2: Targeting Mitochondrial Functions in Heart, Lung, and Blood (HLB) Health and Disease.

Figure 2:

Mitochondria in multiple cell and organ types contribute to the pathogenesis of heart failure or its risk factors. A better understanding of basic mitochondrial biology including the multiplicity of functions played by mitochondria, their role in intra- and inter-cellular communication, and the relationship between mitochondrial genotype and phenotype is a high priority in developing mitochondria-based therapy. Other priority areas emphasized the need for improved tools and/or the development of new approaches for the study of mitochondrial function in humans and the development of strategies for the translation of basic observations to the clinic.