Table 3.

Alteration region of gray matter volume in IBS patients and HCs when SAS and SDS were taken into consideration

Location			Regions	P value	Voxels (mm3)	t value
X	Y	Z
−34.5	−84	−16.5	Occipital lobe, angular gyrus hippocampus	<0.01	770	3.9421
−34.5	12	−13.5	Limbic lobe, insula cingulate gyrus	<0.01	335	3.1116
52.5	21	21	Superior frontal gyrus, medial frontal gyrus, frontal lobe	<0.01	227	4.0585
39	16.5	−7.5	Supramarginal gyrus, superior temporal gyrus, middle temporal gyrus	<0.01	63	2.7957

HCs, healthy controls; IBS, irritable bowel syndrome; SAS, Zung Self‐Rating Anxiety Scale; SDS, Zung Self‐Rating Depression Scale.