Table 5.
Association of the six single-nucleotide polymorphisms at 8q24 with prostate-specific antigen recurrence (Cox proportional hazard model adjusted by age at diagnosis, serum prostate-specific antigen at diagnosis, pathologic T stage, and Gleason grade)
| Risk locus | SNP | Risk allele | Genotype | n | HR (95% CI) | P |
|---|---|---|---|---|---|---|
| 1 | Rs1447295 | A | 77 | 0.3066 | ||
| CC | 1 | |||||
| CA | 0.528 (0.175–1.589) | 0.2556 | ||||
| AA | 0.191 (0.019–1.922) | 0.1599 | ||||
| 2 | Rs6983561 | C | 78 | 0.6753 | ||
| AA | 1 | |||||
| CA | 0.740 (0.240–2.281) | 0.6003 | ||||
| CC | 0.562 (0.157–2.012) | 0.3755 | ||||
| Rs13254738 | C | 75 | 0.8950 | |||
| AA | 1 | |||||
| CA | 0.817 (0.243–2.746) | 0.7435 | ||||
| CC | 0.731 (0.197–2.718) | 0.6400 | ||||
| Broad11934905 | A | 77 | ||||
| GG | 1 | |||||
| AG | 1.813 (0.556–5.912) | 0.3242 | ||||
| 3 | Rs6983267 | G | 75 | |||
| GT | 1 | |||||
| GG | 0.562 (0.138–2.287) | 0.4213 | ||||
| Rs7000448 | T | 78 | 0.2916 | |||
| CC | 1 | |||||
| TC | 0.713 (0.250–2.031) | 0.5268 | ||||
| TT | 0.375 (0.108–1.296) | 0.1210 | ||||
Abbreviation: HR, hazard ratio.