Table 5.

Secondary C(sp³)−H Arylation without Added External Ligands^a

entry	substrate	product	yield, %
1			68
2			44   70b
3			60
4			53   79b
5c			82
6			70
7b,d			75
8b,e			63
9b,f			57

^aAmide 0.5 mmol, hexafluoroisopropanol 3.5 mL. Yields are isolated yields. Please see Supporting Information for details. Ar = 4-FC₆H₄.

^bTen mol % Pd(OAc)₂.

^cCis/trans 5/1.

^dDiastereomer ratio: 1.6/1; 36 h, 110 °C.

^e36 h, 110 °C.

^fDiastereomer ratio: 1.5/1; 36 h, 110 °C. PPY = 4-pyrrolidino-1-pyridyl.