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. 2019 Nov 20;10:1390. doi: 10.3389/fphar.2019.01390

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Copyright © 2019 Qian, Yang, Wang, Zhou, Dang, Zhu, Li and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The lipid-loaded hepatocytes were more sensitive following treatment with 2′-HC and its derivatives. (A) Effects of different concentrations of FFA on cell viability. (B) Effects of FFA (0.3mM) on lipid droplet formation by Oil Red O staining. (C) Effects of different chalcone compounds on cell viability. (D) IC₅₀ of the chalcone compounds. The data are shown as the mean ± SD, ***p < 0.001. ns, no statistical difference.