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. 2019 Nov 20;10:1390. doi: 10.3389/fphar.2019.01390

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Copyright © 2019 Qian, Yang, Wang, Zhou, Dang, Zhu, Li and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2′-HC caused apoptosis of lipid-loaded hepatocytes. (A) Effects of different concentrations of 2′-HC on apoptosis by flow cytometry. (B) Effects of different concentrations of 2′-HC on the total Cytochrome C mRNA expression. (C) Effects of different concentrations of 2′-HC on BAX and BCL-2 mRNA expression. (D) Effects of different concentrations of 2′-HC on mRNA expression of Caspase-3, 6, 7, and 9. (E) Effects of different concentrations of 2′-HC on total Cytochrome C, BAX, BCL-2, Caspase-3 and 9 protein expression. The data are shown as the mean ± SD, *p < 0.05, **p < 0.01,***p < 0.001.