Table 3B.

The expressions of 18 macrophage subset transcription factors and 27 macrophage general transcription factors are modulated in 8 groups of 34 diseases.

Mφ		Autoimmune diseases				Cardiovascular diseases				Digestive inflammatory				Infection diseases				Metabolic diseases				Respiratory diseases				Digestive tumors					Other tumors					Up-regulated disease		Down-regulated disease
Subsets	TFs	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	Number	%	Number	%
M1	HIF1A							↓		↑		↑	↑	↓			↓	↓		↓			↑				↑							↑	↓	6	17.6	6	17.6
	RELA	↓												↓																		↑				1	2.9	2	5.9
	IRF3						↓																									↓	↑	↑		2	5.9	2	5.9
	STAT1	↑		↑	↑		↑		↓	↑		↑	↑	↓		↑	↑						↑				↑		↑	↑	↑		↑	↑	↑	17	50.0	2	5.9
	STAT2								↓				↑			↑	↑	↑											↑	↑		↑	↓	↑	↑	9	26.5	2	5.9
M2a	PPARD			↑		↑	↑			↑			↓															↓	↑	↑		↓	↑	↑		8	23.5	3	8.8
	PPARG	↓				↑	↑	↓	↓	↓			↓	↓	↑						↑				↑	↓	↑		↑		↓			↓		7	20.6	9	26.5
	KLF4	↓				↓				↓			↓	↓			↓									↓		↓	↑	↓	↓		↓	↓	↓	1	2.9	13	38.2
	AKT1													↓																			↑			1	2.9	1	2.9
M2b	MAPK1	↑					↑						↑	↓				↓									↑						↓	↓	↑	5	14.7	4	11.8
	STAT3			↑			↑		↓	↑			↑	↓			↑											↑		↑		↓	↑		↓	8	23.5	4	11.8
M2c	NFKB1						↑		↓					↓																						1	2.9	2	5.9
	NFKB2	↓								↑			↑													↓			↑	↑				↑	↑	6	17.6	2	5.9
	NR3C1				↓	↓	↑					↓	↑	↓				↓		↓								↓		↓	↓	↓		↓	↑	3	8.8	11	32.4
	NFE2					↑	↓		↑				↑	↓			↑								↑						↓		↑	↓		6	17.6	4	11.8
Mhb	ATF1						↑					↓	↓	↓				↓								↑		↓					↓			2	5.9	6	17.6
Mox	NR1H3	↑											↓																↑		↓		↑		↑	4	11.8	2	5.9
Mhem	NR1H2								↑					↓					↑		↓		↓						↑							3	8.8	3	8.8
	NR1H3	↑											↓																↑		↓		↑		↑	4	11.8	2	5.9
uncertain	CREB1	↑					↓							↓			↓	↓											↑	↑			↓	↑		4	11.8	5	14.7
	HMGA1					↑	↑		↑					↓						↓						↑	↑	↑	↑	↑	↑		↑	↑		11	32.4	2	5.9
	SMAD4					↓	↑	↓	↓			↑	↓	↓			↑	↓							↓	↓		↓	↓	↓		↓	↓			3	8.8	13	38.2
	ZNF148							↓	↓					↓				↓					↑				↑						↓	↑		3	8.8	5	14.7
	HBP1					↓			↓					↓				↓					↑					↓		↓			↓			1	2.9	7	20.6
	CKLF	↑					↑		↓				↑	↓				↓		↓						↑	↑		↑		↑		↑			8	23.5	4	11.8
	ZNF281						↑			↑			↑	↓												↑			↑	↑	↑	↑		↑		9	26.5	1	2.9
	FOXO3	↓						↓	↓																				↓	↓		↓				0	0.0	6	17.6
	HEY1					↑	↑		↓			↑		↓			↓			↑			↓		↑	↑		↓		↑	↓	↓		↓	↑	8	23.5	8	23.5
	ETS2	↓				↓	↓	↓	↓				↑	↓						↓					↑		↓	↑	↑	↑		↓	↓	↓		6	17.6	11	32.4
	HIF1A					↑	↓		↑	↑		↑	↑	↓			↓						↑				↑							↑	↓	8	23.5	4	11.8
	STAT4		↓										↑															↓							↑	2	5.9	2	5.9
	MELTF			↓		↑						↓	↑													↑			↑	↑			↑	↑		7	20.6	2	5.9
	BATF3											↑	↑																				↑			3	8.8	0	0.0
	NFE2								↑				↑	↓			↑		↑		↓				↑						↓		↑	↓		6	17.6	4	11.8
	NFKB1						↑		↓					↓																						1	2.9	2	5.9
	RIT1			↑		↑	↑			↑			↓	↓				↓					↑				↑	↓	↑			↓			↑	8	23.5	5	14.7
	HIVEP1						↑							↓							↓		↑													2	5.9	2	5.9
	JUNB	↓							↑				↑	↓			↓			↓	↑						↓		↑		↓			↓		4	11.8	7	20.6
	NFX1	↓					↑		↓			↑		↓			↑						↑													4	11.8	3	8.8
	FOXN3					↓		↓	↓			↓	↓	↓			↓	↑								↓		↓		↓	↓		↓			1	2.9	12	35.3
	STAT3			↑					↓	↑			↑	↓			↑	↓		↓								↑		↑		↓	↑		↓	7	20.6	6	17.6
	PWWP3A																																			0	0.0	0	0.0
	MXD4							↓	↓											↑								↓			↓			↓		1	2.9	5	14.7
	E2F3						↑		↓			↑	↑				↑									↑	↑	↑	↑	↑	↑	↑	↑	↑		13	38.2	1	2.9
	CEBPD	↓										↑	↑					↓			↓								↓			↓		↓		2	5.9	6	17.6
	NME1					↑	↑	↓	↓		↑	↑	↑	↓				↓								↑		↑		↑	↑	↑	↑	↑		12	35.3	4	11.8
Up- regulated gene	Number	5	0	4	1	8	18	0	4	7	1	9	18	0	2	2	7	2	1	2	2	0	7	0	4	8	9	5	17	13	6	5	13	19	12
	%	12.2	0.0	9.8	2.4	19.5	43.9	0.0	9.8	17.1	2.4	22.0	43.9	0.0	4.9	4.9	17.1	4.9	2.4	4.9	4.9	0.0	17.1	0.0	9.8	19.5	22.0	12.2	41.5	31.7	14.6	12.2	31.7	46.3	26.8
Down-regulated gene	Number	9	1	1	1	6	4	8	18	2	0	4	8	28	0	0	6	12	0	6	3	0	2	0	1	5	2	11	3	6	9	10	10	13	4
	%	20.0	2.2	2.2	2.2	13.3	8.9	17.8	40.0	4.4	0.0	8.9	17.8	62.2	0.0	0.0	13.3	26.7	0.0	13.3	6.7	0.0	4.4	0.0	2.2	11.1	4.4	24.4	6.7	13.3	20.0	22.2	22.2	28.9	8.9

First, some Mφ transcription factors (TFs) were upregulated in more than 30% of the 34 diseases, including M1 TF STAT1 and three other Mφ TFs, namely HMGA1, E2F3, and NME1. Second, the diseases having Mφ TFs upregulated in more than 30% among the 34 diseases were of six types, namely #6 coronary artery disease, #12 Crohn's colitis, #28 hepatocellular cancer, #29 esophageal cancer, #32 ovarian carcinoma, and #33 lung cancer (For detailed expression data, see the Figures S13–S16). 1, Rheumatoid arthritis; 2, Systemic lupus erythematosus; 3, Psoriasis; 4, Asthma; 5, Myocardial infarction; 6, Coronary artery disease; 7, Abdominal aortic aneurysm; 8, Aortic occlusive disease; 9, Ulcerative colitis; 10, Gastritis; 11, Crohn's ileitis; 12, Crohn's colitis; 13, Tuberculous Meningitis coinfected with HIV; 14, Sepsis; 15, Chronic Hepatitis C virus; 16, Tuberculosis; 17, Type 2 diabetes; 18, Type 1 diabetes; 19, Metabolic syndrome; 20, Familial Hypercholesterolemia; 21, Chronic obstructive pulmonary disease; 22, Pulmonary arterial hypertension; 23, Asthma; 24, Pneumonia; 25, Gastric adenocarcinoma; 26, Hepatocellular cancer; 27, Colorectal adenocarcinoma; 28, Pancreatic cancer; 29, Esophageal cancer; 30, Breast Adenocarcinoma; 31, Prostate cancer; 32, Ovarian carcinoma; 33, Lung cancer; 34, Renal carcinoma.