Table 3C.

Ingenuity Pathway Analyses showed that the top 10 pathways involved in 31 macrophage markers of 10 Mφ subsets are modulated in 8 groups of 34 diseases.

Pathways modulated by Mφ markers		Disease type	Autoimmune diseases	Cardiovascular diseases	Digestive inflammatory disease	Infection disease	Metabolic diseases	Respiratory disease	Digestive tumors	Other tumors
Up-regulated pathways in eight group of diseases	Hematopoiesis from Pluripotent Stem Cells	1		↑
	IL-17 Signaling	1								↑
	Acute Phase Response Signaling	1						↑
	Glucocorticoid Receptor Signaling⋆	2				↑		↑
	IL-17A Signaling in Gastric Cells⋆	3	↑			↑				↑
	Pathogenesis of Multiple Sclerosis	6	↑	↑		↑	↑		↑	↑
	Agranulocyte Adhesion and Diapedesis	7	↑	↑	↑	↑	↑		↑	↑
	Granulocyte Adhesion and Diapedesis	7	↑	↑	↑	↑	↑		↑	↑
	N(↑)		4	4	2	5	3	2	3	5
Down-regulated pathways in eight group of diseases	Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses	1	↓
	TREM1 Signaling	1	↓
	IL-12 Signaling and Production in Macrophages⋆	1		↓
	Role of BRCA1 in DNA Damage Response⋆	1			↓
	Sirtuin Signaling Pathway⋆	1			↓
	Unfolded protein response⋆	1			↓
	Extrinsic Prothrombin Activation Pathway	1				↓
	NRF2-Mediated Oxidative Stress Response⋆	1				↓
	Thioredoxin Pathway	1				↓
	Vitamin-C Transport	1				↓
	Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	1					↓
	Aryl Hydrocarbon Receptor Signaling	1								↓
	Atherosclerosis Signaling	1								↓
	Xenobiotic Metabolism Signaling	1								↓
	Allograft Rejection Signaling	2						↓	↓
	Calclum-induced T Lymphocyte Apoptosis	2						↓	↓
	OX40 Signaling Pathway	2						↓	↓
	T Helper Cell Differentiation	2						↓	↓
	Role of IL-17A in Psoriasis	2		↓			↓
	CD40 Signaling⋆	2			↓		↓
	Arginine Degradaion VI(Arginase 2 Pathway)	3			↓	↓	↓
	Antigen Presentation Pathway	3		↓				↓	↓
	Autoimmune Thyroid Disease Signaling	3		↓				↓	↓
	B Cell Development	3		↓				↓	↓
	Nur77 Signaling in T Lymphocytes	3		↓				↓	↓
	Citrulline Biosynthesis	3			↓	↓	↓
	Urea Cycle	3			↓	↓	↓
	Superpathway of Citrulline Metabolism	3			↓	↓	↓
	Arginine Degradation I (Arginase Pathway)	3			↓	↓	↓
	N(↓)		2	6	9	9	8	8	8	3
Dual-regulated pathways in eight groups of diseases	Hepatic Fibrosis/Hepatic Stellate Cell Activation	2	↓							↑
	Role of IL-17F in Allergic Inflammatory Airway Diseases⋆	2							↑	↓
	Dendritic Cell Maturation⋆	3	↑	↓	↑
	Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F	3	↓					↑		↑
	LXR/RXR Activation	3					↓		↑	↓
	Altered T Cell and B Cell Signaling in Rheumatoid Arthritis	5	↑↓	↑↓	↑		↑	↑↓
	Differential Regulation of Cytokine Production in Macrophages and T Heiper Cells by IL-17A and IL-17F	6	↓	↑	↑		↑		↑	↑↓
	Neuroinflammation Signaling Pathway	6	↓			↑↓	↑	↑	↓	↑↓
	Graft-vs.-Host Disease Signaling	7	↑	↓	↑		↑	↑↓	↓	↓
	IL-10 Signaling	7	↓	↑	↑↓	↑	↑↓	↑	↑
	Role of Cytokines in Mediating Communication between Immune Cells	7	↑↓	↑↓	↑	↑		↑	↑	↓
	Communication between Innate and Adaptive Immune Cells	8	↑↓	↑	↑	↑	↑	↑	↑	↑
	Role of Hypercytokinemia/Hyperchemokinemia in the Pathogenesis of Influenza	8	↑	↑	↑	↑	↑	↑	↑	↓
	N(↑)		3	4	7	4	6	6	7	3
	N(↓)		5	2	0	0	1	0	2	5
	N(↑↓)		3	2	1	1	1	2	0	2

^⋆The pathways modulated in 8 groups of 34 diseases both by 31 Mφ markers and 41 Mφ transcription factors.