Table 4A.
Mechanism II: M1 polarization promotes the expressions of M1- and M2c-transcription factors (TFs; NFkB1, NFkB2, and NR3C1) but inhibits the expression of M2a TF PPARg; M2 polarization specifically upregulates M2a TF KLF4, and M1 macrophages (Mφ) express higher levels of TFs, STAT1, STAT2, STAT3, and NF-kB than M0 Mφ.
| GEO ID | GSE85346 | ||||
|---|---|---|---|---|---|
| Comparision | M1 vs. M0 | M2a vs. M0 | M2b vs. M0 | M2c vs. M0 | |
| M1 TFs | HIF1A | 2.247 | |||
| RELA | 5.401 | ||||
| IRF3 | 2.132 | ||||
| STAT1 | 9.433 | 3.077 | |||
| STAT2 | 3.353 | 1.787 | |||
| M2a TFs | PPARD | ||||
| PPARG | −14.550 | −1.988 | |||
| KLF4 | 4.123 | ||||
| AKT1 | |||||
| M2b TFs | MAPK1 | ||||
| STAT3 | 5.058 | 1.699 | |||
| M2c TFs | NFKB1 | 4.065 | 1.787 | ||
| NFKB2 | 8.639 | ||||
| NR3C1 | 2.439 | ||||
| NFE2 | |||||
| Mox TFs | NR1H3 | ||||
| M(hb) TFs | ATF1 | ||||
| Mhem TFs | NR1H3 | ||||
| NR1H2 | |||||
| Up | 9/18 | 1/18 | 3/18 | 1/18 | |
| Down | 1/18 | 0/18 | 1/18 | 0/18 | |