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. 2019 Oct;189(10):2019–2035. doi: 10.1016/j.ajpath.2019.06.005

Figure 5.

Figure 5

Obesity-associated extracellular matrix (ECM) impacts macrophage polarization in vitro. A and B: A greater proportion of bone marrow–derived macrophages cultured on obese decellularized ECM expresses the anti-inflammatory macrophage markers CD206 (A) and arginase-1 (B), when exposed to IL-4 and IL-13, as determined by immunofluorescence confocal image analysis. A t-test analysis was used. Data are expressed as means ± SD (A and B). n = 3 independent experiments, with 15 images per condition per experiment (A and B). *P < 0.05, ***P < 0.001. Scale bars = 25 μm (A and B). Fn, fibronectin.