Figure 7.

Global breast density is not predictive of either fibrosis or macrophage burden within adipose tissue interstitium. A: Histologic breast density, assessed by the ratio of fibrous tissue/adipose tissue,⁷⁷ is inversely correlated with body mass index. Kruskal-Wallis analysis was performed. B and C: The distribution of mammographic density patterns is significantly different between body condition (χ² analysis) and is not predictive of interstitial fibrosis (Kruskal-Wallis analysis). D and E: Macrophage burden, as determined by both CD206 immunohistochemistry and CIBERSORT analysis of RNA transcripts, cannot be predicted by mammographic density pattern; Kruskal-Wallis analysis was performed. Data are expressed as median, interquartile range, and minimum-maximum (A) or median and interquartile range (C–E). n = 50 sections (A); n = 26 (B–E). *P < 0.05, ***P < 0.001. Scale bars = 4 mm (A). H&E, hematoxylin and eosin; M2, anti-inflammatory.