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. 2019 Nov 20;10:2669. doi: 10.3389/fimmu.2019.02669

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Copyright © 2019 Nagaoka, Kanoi, Jinoka, Morita, Arumugam, Palacpac, Egwang, Horii, Tsuboi and Takashima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Interaction between PfGAMA and PfMSP10 R1 is needed for erythrocyte invasion. Lipid raft-like membrane on the surface of merozoites would promote the interaction between the two GPI anchored proteins. (B) Blocking interaction between PfGAMA and PfMSP10 R1 with antibodies against PfMSP10 R1 impedes erythrocyte invasion.