Table 1.
Study characteristics of included studies (n = 77 trials, 6472 participants).
| Reported outcomes |
||||
|---|---|---|---|---|
| Pain | Function | Performance | QoL | |
| No. of comparisons (no. of RCTs) | 70 (69) | 65 (64) | 73 (72) | 34 (34) |
| No. of participants | 6072 | 5829 | 5913 | 3058 |
| % females per trial (range) | 73.2 (40.4–100.0) | 73.2 (40.4–100.0) | 73.3 (40.4–100.0) | 72.6 (40.4–100.0) |
| Age, years, median (range) | 64.8 (41.3–84.4) | 65 (41.3–84.4) | 64.8 (41.3–77.0) | 64.9 (49.4–84.4) |
| BMI, kg/m2, median (range) | 29.8 (23.8–38.1) | 29.8 (23.8–38.1) | 29.6 (23.8–38.1) | 29.9 (23.8–37.3) |
| Joint studied (no. of RCTs [%]) | ||||
| Knee | 55 (80) | 50 (78) | 56 (78) | 24 (71) |
| Hip | 8 (12) | 9 (14) | 9 (13) | 7 (21) |
| Both | 6 (9) | 5 (8) | 7 (10) | 3 (9) |
| OA definition* | ||||
| ACR | 32 | 31 | 35 | 13 |
| Radiographic | 38 | 37 | 39 | 19 |
| Trial data points, months | ||||
| 1 | 17 | 16 | 16 | 13 |
| 2 | 26 | 26 | 30 | 9 |
| 3 | 21 | 17 | 21 | 7 |
| 6 | 3 | 3 | 1 | 3 |
| ≥ 12 | 3 | 3 | 5 | 2 |
QoL: quality of life; BMI: body mass index; ACR: American College of Rheumatology.
*
Radiographic diagnosis was mandatory in some studies and some studies merely indicated that ACR criteria was fulfilled.