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. 2019 Nov 19;15:2790–2797. doi: 10.3762/bjoc.15.271

Scheme 4.

Scheme 4

Preparation of amides 17. Representative reagents and conditionsa: (a) HBTU (1.1 equiv), iPr2NEt (2.5 equiv), DMF, rt, 15 min; then amine 18 (1.05 equiv). aThese reactions were performed once for each amide and have not been optimised. DMF, N,N-dimethylformamide; HBTU, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate.