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Significance and p values of experimental groups using the highest dose. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001 versus control. N.S. indicates non-significant.
| Drug group | Significance | p value |
| CuFe2O4 | N.S. | 0.8058 |
| HYPS | N.S. | 0.3059 |
| CuFe2O4/HYPS | N.S. | 0.9996 |
| cisplatin | **** | <0.0001 |
| cisplatin/CuFe2O4/HYPS | **** | <0.0001 |
