Table 4.
Analyses Reporting Unadjusted and Adjusted Associations With Cardiovascular Outcomes, by Outcome and Measurement Type
| Cardiovascular Outcome and Measurement Type |
Unadjusted Analyses* | Lipid-Adjusted Analyses† | Unadjusted Versus Lipid-Adjusted Analyses | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studies, n‡ |
Participants, n |
Result |
Studies, n‡ |
Participants, n |
Result |
Studies, n‡ |
Participants, n |
Result |
|||||
| Significant Analyses, n§ |
Nonsignificant Analyses, n |
Significant Analyses, n |
Nonsignificant Analyses, n |
Analyses Remained Significant, n |
Significant Analyses Became Nonsignificant, n |
Analyses Remained Nonsignificant, n |
|||||||
| Coronary artery disease, incident | |||||||||||||
| Size | 15 | 16 565∥ | 12 | 6 | 9 | 4579 | 3 | 6 | 8 | 2507 | 2 | 5 | 1 |
| Number | 9 | 6101 | 7 | 2 | 3 | 6754 | 3 | 3 | 6214 | 3 | |||
| Pattern | 11 | 11 511 | 8 | 5 | 5 | 5927 | 3 | 3 | 5 | 5927 | 3 | 2 | 1 |
| Coronary artery disease, progression | |||||||||||||
| Size | 7 | 6531 | 4 | 3 | 4 | 5949 | 1 | 3 | 4 | 5949 | 1 | 1 | 2 |
| Number | 1 | 111 | 1 | 1 | 111 | 1 | 1 | 111 | 1 | ||||
| Pattern | 6 | 6366 | 4 | 2 | 3 | 5752 | 2 | 1 | 3 | 5752 | 2 | 1 | |
| Cerebrovascular disease, incident | |||||||||||||
| Size | 1 | 148 | 1 | 1 | 148 | 1 | 1 | 148 | 1 | ||||
| Number | 1 | 148 | 1 | ||||||||||
| Pattern | 1 | 148 | 1 | ||||||||||
| Incident disease or progression (total of all studies) | |||||||||||||
| Size | 23 | 23 244¶ | 17 | 9 | 14 | 10 675 | 4 | 10 | 13 | 8603 | 3 | 7 | 3 |
| Number | 11 | 6360 | 7 | 4 | 4 | 6865 | 3 | 1 | 4 | 6325 | 3 | 1 | |
| Pattern | 18 | 18 025 | 13 | 7 | 8 | 11 679 | 5 | 4 | 9 | 11 679 | 5 | 2 | 2 |
Associations are not adjusted for other lipids but may be adjusted for other cardiovascular risk factors.
Associations are adjusted for other lipids, including low-density lipoprotein cholesterol or high-density lipoprotein cholesterol levels; ratio of total to high-density lipoprotein cholesterol level; and possibly other cardiovascular risk factors, such as age, weight, and diabetes status.
The number of analyses may exceed the number of studies.
Includes associations that were reported to have been found, but the level of statistical significance was not reported.
The number of participants could also be 17 275 (the number of analyzed participants was unclear in 1 study).
The number of participants could also be 23 954 (the number of analyzed participants was unclear in 1 study).