Appendix Table 1.

Search Strategy^*

Step	Search Terms
1	(ldl or ldl-c).mp. or exp Cholesterol, LDL/ or exp Lipoproteins, LDL/
2	ldl cholesterol.mp.
3	or/1–2
4	particle size.mp. or exp Particle Size/
5	(subfraction$ or subclass$).mp.
6	particle density.mp.
7	exp Nuclear Magnetic Resonance, Biomolecular/ or exp Magnetic Resonance Spectroscopy/
8	(nuclear magnetic resonance or nmr or magnetic resonance spectroscopy).mp.
9	exp Chromatography, High Pressure Liquid/ or exp Chromatography/
10	(chromatography or hplc or fplc).mp.
11	ultracentrifugation.mp. or exp Ultracentrifugation/
12	centrifugation.mp. or exp Centrifugation/
13	exp Electrophoresis/ or electrophoresis.mp.
14	or/4–13
15	3 and 14
16	limit 15 to (humans and english language)†

^*Databases used were Ovid MEDLINE, CAB Abstracts, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.

^†Limit was not valid in CAB Abstracts, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews; records were retained.