. Author manuscript; available in PMC: 2019 Nov 27.

Published in final edited form as: Diabet Med. 2017 Dec;34(12):1696–1700. doi: 10.1111/dme.13529

Table 2.

Proportion of association between maternal gestational diabetes and offspring adiposity explained by offspring obesity genetic risk score

Exposure	Outcome	Intermediate variable	β^* (95% CI)	Proportion explained, % (95% CI)
GDM	Child BMI	None	1.72 (0.70, 2.74)	-
GDM	Child BMI	Obesity GRS^b	1.59 (0.57, 2.61)	7.7 (−3.3, 18.8)
	Child waist circumference	None	5.26 (2.46, 8.06)	-
	Child waist circumference	Obesity GRS^b	4.96 (2.16, 7.75)	5.8 (−3.1, 14.8)

GDM, gestational diabetes mellitus; GRS, genetic risk score.

β coefficient (in kg/m² for child BMI and cm for child waist circumference) for association between exposure and outcome in models without and with the intermediate variable.