Table 4.
Outcomes of patients aged ≥60 years undergoing allogeneic transplantation during the pre-TOP and TOP multidisciplinary clinic eras
| Outcome | Pre-TOP (2005-2012), n = 74 | TOP Initial (March 2013-2014) | TOP Modern (2015-2018) | ||
|---|---|---|---|---|---|
| n = 27 | P* | n = 58 | P* | ||
| Inpatient deaths during initial hospitalization, n (%) | 13 (17.6) | 0 (0) | .018 | 0 (0) | <.001 |
| Length of inpatient stay, median (IQR), d† | 19 (15-23) | 15 (13-19) | .045 | 14 (13-17) | <.001 |
| Events by day 100, n/N (%) or n (%) | |||||
| Discharge to nursing facility† | 11/61 (18) | 1 (3.7) | .096 | 1 (1.7) | .0043 |
| Readmission† | 36/61 (59) | 16 (59.3) | 1 | 27 (46.5) | .20 |
| Death | 16 (21.6) | 3 (11.1) | .26 | 3 (5.2) | .011 |
| Events by 1 y, % | |||||
| OS | 43.2 | 44.4 | .66 | 70‡ | <.001 |
| NRM | 43.2 | 37 | 1 | 18‡ | .012 |
IQR, interquartile range.
*
Compared with pre-TOP cohort.
†
Excludes patients with death during initial inpatient transplant encounter.
‡
Excludes 8 patients who received allogeneic transplant in 2018.