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. 2019 Nov 27;14(11):e0225760. doi: 10.1371/journal.pone.0225760

Fig 7. Intracerebral ventricular infusion of IL-1β receptor antagonist prevents blood-brain-barrier disruption induced by Nef expression in the rat hippocampus.

Fig 7

(A) Immunofluorescence of claudin-5: the green represents the tight junction claudin-5, while the blue represents the nucleus of the cells. The results showed IL-1ra partially inhibits BBB disruption caused Nef. (B) Quantitative analysis of BBB tight junction claudin-5 showed that Nef decreased (by twofold) the expression of the tight junction compared to Nef with the IL-1β receptor antagonist in both hemispheres. N = 4 to 6 rats per group. One-way ANOVA (followed by Holm–Sidak’s multiple comparisons test) was used to determine the difference between naïve, Nef + placebo, and Nef + IL1-Ra. Data are expressed as means ± S.E.M.