Table 4. ITGAM haplotype frequencies and association analysis in patients with SLE and controls from Mexico City and Yucatan.
The order of the SNPs is: rs34572943-rs1143679-rs9888739-rs1143683.
| Population | Haplotype | SLE (%) | Controls (%) | OR | 95% CI | Fisher’s P | Pc |
|---|---|---|---|---|---|---|---|
| Mexico City |
GGCC | 85.0 | 87.9 | 0.74 | 0.53–1.02 | 0.06 | 0.49 |
| AATT | 9.6 | 4.0 | 2.532 | 1.65–3.88 | 1.17x10-5 | 2.1x10-5 | |
| GACC | 0.7 | 2.3 | 0.307 | 0.105–0.89 | 0.02 | 3.3x10-2 | |
| GGCT | 1.4 | 1.4 | 1.019 | 0.42–2.45 | 0.96 | 1.0 | |
| GGTC | 1.3 | 1.2 | 1.085 | 0.42–2.79 | 0.86 | 0.99 | |
| Yucatan | GGCC | 82.9 | 95.7 | 0.207 | 0.09–0.46 | 4.17x10-5 | 2.1x10-5 |
| AATT | 8.4 | 0.4 | 21.187 | 3.8–118.10 | 6.74x10-5 | 7.3x10-5 | |
| GGCT | 3.2 | 1.3 | 2.52 | 0.56–11.3 | 0.21 | 0.69 | |
| GGTC | 0.8 | 2.2 | 0.35 | 0.05–2.15 | 0.41 | 0.97 |
OR = odds ratio. CI, confidence interval. pc: corrected p-value after 100,000 permutations.