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. 2019 Nov 15;15(11):e1008490. doi: 10.1371/journal.pgen.1008490

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Fig 1 — (A) This example of the two-generation family structure has a founding couple with $n_{1}^{D} = 4$ affected children and $n_{1}^{T} = 4$ total children. (B) This example of the three-generation family structure has a founding couple with $n_{1}^{D} = 2$ affected children, $n_{1}^{T} = 3$ total children, $n_{2}^{D} = 4$ affected grandchildren, and $n_{2}^{T} = 9$ total grandchildren.