Table 3. Using fungal hits to search for FFAT motifs in non-fungal homologues.
| Name | FFAT score | Family of orthologues | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| alternate name | species group | FFAFFATscores ≤2.5 | size of family | observed motifs | expected background (random) | p-value (-log10) | |||||||||||
| 2.5 | 2.0 | 1.5 | 0.0–1.0 | 2.5 | 2.0 | 1.5 | 0.0 – 1.0 | ≤2.5 | ≤2.0 | ≤1.5 | ≤1.0 | ||||||
| EDE1 | 1.5 | EPS15 | non-fungi | 2.6% | 391 | 9 | 1 | 0 | 0 | 17 | 4.6 | 0.5 | 0.1 | / | / | / | / |
| EFR3 | 2.0 | animals | 3.0% | 364 | 11 | 0 | 0 | 0 | 8.2 | 1.9 | 0.4 | 0.0 | 0.0 | / | / | / | |
| plants | 3.0% | 560 | 11 | 6 | 0 | 0 | 16 | 2.7 | 0.8 | 0.1 | 0.2 | 0.4 | 0.5 | / | |||
| ENT3 | 2.0 | Epsin | animals | 5.5% | 218 | 11 | 1 | 0 | 0 | 2.6 | 0.8 | 0.1 | 0.0 | 1.5 | 0.0 | / | / |
| plants | 5.9% | 170 | 8 | 2 | 0 | 0 | 3.6 | 1.0 | 0.3 | 0.0 | 0.7 | 0.1 | / | / | |||
| ERB1 | 1.5 | BOP1 | All | 17% | 904 | 91 | 41 | 31 | 2 | 36 | 7.9 | 2.5 | 0.3 | 15 | 11 | 6 | 0.6 |
| KRI1 | 1.0 | animals | 14% | 226 | 16 | 16 | 1 | 0 | 19 | 5.8 | 1.5 | 0.3 | 0.4 | 1.2 | / | / | |
| plants | 39% | 79 | 17 | 14 | 5 | 0 | 6.7 | 2.5 | 0.5 | 0.1 | 4.0 | 3.1 | 1.2 | / | |||
| MSH6 | 2.0 | non-fungi | 6.7% | 794 | 44 | 11 | 0 | 0 | 30 | 7.0 | 0.6 | 0.1 | 1.1 | 0.4 | / | / | |
| NOP2 | 1.5 | bacteria | 1.0% | 620 | 4 | 1 | 0 | 1 | 8.2 | 1.6 | 0.4 | 0.0 | / | 0.0 | / | / | |
| animals | 82% | 56 | 48 | 1 | 0 | 0 | 2.5 | 0.8 | 0.0 | 0.0 | 10 | / | |||||
| plants | 9.8% | 122 | 10 | 1 | 1 | 0 | 3.3 | 1.0 | 0.2 | 0.0 | 1.2 | 0.2 | |||||
| RQC1 | 1.5 | TCF25 | animals | 6.2% | 324 | 21 | 0 | 0 | 0 | 7.4 | 1.8 | 0.5 | 0.0 | 1.4 | / | ||
| plants | 14% | 107 | 15 | 0 | 0 | 0 | 4.1 | 0.9 | 0.0 | 0.0 | 1.6 | / | |||||
| SEC2 | 2.5 | non-fungi | 0.0% | 76 | 1 | 0 | 0 | 0 | 1.1 | 0.2 | 0.0 | 0.0 | / | / | / | / | |
| SXM1 | 2.0 | Cse1 | all | 9.9% | 565 | 44 | 20 | 1 | 0 | 37 | 7.0 | 2.0 | 0.5 | 1.1 | 1.4 | ||
| UBP10 | 1.5 | USP36 | animals | 24% | 306 | 1 | 0 | 0 | 0 | 1.2 | 0.8 | 0.0 | 0.0 | / | / | / | / |
| UBR1 | 1.5 | UBR4 | non-fungi | 32% | 507 | 147 | 20 | 4 | 3 | 58 | 12 | 2.2 | 0.4 | 10 | 1.3 | 0.8 | 0.8 |
| VID27 | 1.5 | non-fungi | 24% | 304 | 47 | 26 | 6 | 7 | 10 | 3.0 | 0.8 | 0.0 | 12 | 7 | 3.0 | 2.1 | |
| VPS13 | 2.5 | all | 18% | 3860 | 415 | 210 | 83 | 138 | 242 | 50 | 17 | 3.0 | 55 | 58 | 38 | 29 | |
Notes: Alternate names for human homologues and range of species searched are in column 3. For some families, different species groups were searched separately (indicated in column 4). Coloring, p values and exclusions as in Table 2. Where different groups of species within an overall family have different significance levels, only the most significant group is coloued (column 4). FFAT = two phenylalanines in an acidic tract. "/" indicates that χ2 is not valid or only motif was observed.