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. 2019 Nov 15;3(4):046102. doi: 10.1063/1.5118212

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© Author(s).

2473-2877/2019/3(4)/046102/9

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 2. — Velocity response of sickle cell blood to oxygen. (a) Oxygen tension was cyclically modulated between 160 and 0 mm Hg and blood velocity tracked and analyzed. A representative SCD sample followed by a healthy control are shown. (b) Representative average velocity at 160 and 0 mm Hg oxygen tension for sickle and normal blood samples. The error bars represent the measurement standard deviation for the multiple oxygen cycles measured and used to determine the average relative velocity drop. (c) These values were then compared using Pearson's coefficient to assess linearity with respect to hemoglobin fraction values obtained using high performance liquid chromatography, but no significant linear correlation was found relating hemoglobin fractions to rheology (p > 0.05 for all metrics using Pearson correlation), n = 9 patients.