Table 3. Stratified analyses between rs2275913 polymorphisms and the risk of colorectal cancer.
| Variable | (Case/Control) | Heterozygous model | Homozygous model | Recessive model | Dominant model | ||
|---|---|---|---|---|---|---|---|
| rs2275913 | GG | GA | AA | GA vs GG | AA vs GG | AA vs GG+GA | AA+GA vs GG |
| Sex | |||||||
| Male | 38/46 | 23/30 | 8/3 | 0.93 (0.46–1.86); 0.833 | 3.23 (0.80–13.02); 0.100 | 3.32 (0.85–13.06); 0.086 | 1.14 (0.59–2.18); 0.699 |
| Female | 122/185 | 131/139 | 29/28 | 1.42 (1.02–1.98); 0.037 | 1.56 (0.89–2.76); 0.124 | 1.32 (0.77–2.28); 0.315 | 1.45 (1.05–1.98); 0.022 |
| Smoking | |||||||
| Yes | 86/118 | 79/88 | 26/15 | 1.23 (0.82–1.86); 0.321 | 2.38 (1.19–4.76); 0.014 | 2.16 (1.11–4.22); 0.023 | 1.40 (0.95–2.06); 0.091 |
| No | 74/113 | 75/81 | 11/16 | 1.40 (0.91–2.15); 0.124 | 1.04 (0.46–2.37); 0.925 | 0.89 (0.40–1.98); 0.776 | 1.34 (0.89–2.03); 0.163 |
| Alcohol | |||||||
| Yes | 102/126 | 87/100 | 16/22 | 1.07 (0.72–1.57); 0.747 | 0.89 (0.45–1.79); 0.746 | 0.87 (0.44–1.70); 0.675 | 1.04 (0.71–1.50); 0.857 |
| No | 58/105 | 67/69 | 21/9 | 1.76 (1.11–2.80); 0.017 | 4.22 (1.72–9.82); <0.001 | 3.24 (1.44–7.33); 0.005 | 2.04 (1.31–3.18); 0.002 |
| Age (years) | |||||||
| <60 | 58/81 | 66/64 | 7/13 | 1.44 (0.89–2.33); 0.138 | 0.75 (0.28–2.00); 0.568 | 0.63 (0.24–1.63); 0.340 | 1.32 (0.83–2.11); 0.237 |
| ≥60 | 102/150 | 88/105 | 30/18 | 1.23 (0.84–1.79); 0.295 | 2.44 (1.29–4.60); 0.006 | 2.23 (1.21–4.12); 0.011 | 1.40 (0.98–2.00); 0.064 |
| BMI | |||||||
| <25 | 78/126 | 75/88 | 17/16 | 1.37 (0.90–2.08); 0.144 | 1.70 (0.81–3.57); 0.158 | 1.48 (0.73–3.02); 0.282 | 1.42 (0.95–2.11); 0.086 |
| ≥25 | 82/105 | 79/81 | 20/15 | 1.25 (0.82–1.91); 0.304 | 1.71 (0.82–3.54); 0.150 | 1.54 (0.76–3.11); 0.228 | 1.32 (0.88–1.98); 0.176 |
| rs763780 | TT | TC | CC | TC vs TT | CC vs TT | CC vs TT+TC | CC+TC vs TT |
|---|---|---|---|---|---|---|---|
| Sex | |||||||
| Male | 46/51 | 20/23 | 3/5 | 0.96 (0.47–1.98); 0.921 | 0.67 (0.15–3.00); 0.591 | 0.67 (0.16–2.92); 0.597 | 0.91 (0.46–1.80); 0.788 |
| Female | 195/233 | 80/109 | 7/11 | 0.87 (0.62–1.23); 0.442 | 0.76 (0.29–1.99); 0.573 | 0.79 (0.30–2.06); 0.629 | 0.86 (0.62–1.21); 0.388 |
| Smoking | |||||||
| Yes | 133/144 | 52/68 | 7/9 | 0.83 (0.54–1.27); 0.391 | 0.84 (0.31–2.33); 0.740 | 0.89 (0.33–2.44); 0.823 | 0.83 (0.55–1.25); 0.375 |
| No | 108/140 | 48/64 | 3/7 | 0.97 (0.62–1.52); 0.878 | 0.55 (0.14–2.18); 0.397 | 0.56 (0.14–2.19); 0.403 | 0.93 (0.596–1.43); 0.726 |
| Alcohol | |||||||
| Yes | 133/168 | 67/74 | 5/7 | 1.14 (0.76–1.70); 0.531 | 0.90 (0.28–2.89); 0.855 | 0.86 (0.27–2.75); 0.800 | 1.12 (0.76–1.65); 0.581 |
| No | 108/116 | 33/58 | 5/9 | 0.61 (0.37–1.01); 0.054 | 0.72 (0.25–2.08); 0.537 | 0.82 (0.29–2.37); 0.717 | 0.63 (0.39–1.01); 0.051 |
| Age (years) | |||||||
| <60 | 88/100 | 38/52 | 5/7 | 0.83 (0.50–1.38); 0.473 | 0.81 (0.25–2.65); 0.730 | 0.86 (0.27–2.78); 0.803 | 0.83 (0.51–1.35); 0.447 |
| ≥60 | 153/184 | 62/80 | 5/9 | 0.93 (0.62–1.38); 0.707 | 0.67 (0.22–2.03); 0.472 | 0.68 (0.22–2.06); 0.494 | 0.90 (0.61–1.32); 0.591 |
| BMI | |||||||
| <25 | 114/140 | 48/80 | 7/9 | 0.73 (0.47–1.13); 0.159 | 0.95 (0.34–2.63); 0.919 | 1.05 (0.38–2.88); 0.922 | 0.75 (0.50–1.14); 0.184 |
| ≥25 | 127/144 | 52/52 | 3/7 | 1.13 (0.72–1.78); 0.586 | 0.49 (0.12–1.92); 0.303 | 0.47 (0.12–1.84); 0.279 | 1.06 (0.68–1.64); 0.804 |
BMI, body mass index.
Bold values are statistically significant (P <0.05).