Fig. 1.

Functional and clinically significant FCGR2C variants and their genotype distribution in HIV-1-infected South Africans with differential control of HIV-1 infection—controllers (n = 71) and progressors (n = 73). aFCGR arrangement on chromosome 1q23.3. FCGR2C is duplicated/deleted in two different genomic segments, copy number variable region 1 (CNR1) and CNR2 (grey bars). FCGR2C variants with a minor allele frequency above 5%—c.-386G>C, c.134-96C>T, c.169T>C (p.X57Q) and CNR1—were assessed for an association with HIV-1 disease progression. b Odds ratios (OR), confidence intervals (CI) and P-values for the c.134-96C>T association in different HIV-1 controller groups—elite controllers (ECs), viraemic controllers (VCs), and high viral load long-term non-progressors (HVL LTNPs). *Fisher’s exact test of genotype distributions