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. 2019 Nov 21;10:2710. doi: 10.3389/fimmu.2019.02710

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Copyright © 2019 Tao, Li, Gao, Wang and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective impairment of iNKT1 differentiation in Foxo1 deficient mice. (A) Top panels: T-bet and RORγt staining of thymic iNKT cells. Bottom panels: PLZF and GATA3 staining of RORγt⁻T-bet⁻ iNKT cells. (B) Percentages of iNKT effector lineages. Data shown are representative or pooled from five experiments. Connecting lines indicate individual pairs of sex- and age-matched test and control mice in each experiment. One pair of mice was examined in each experiment. *p < 0.05; **p < 0.01 determined by two-tail pair-wised Student t-test.