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. 2019 Nov 21;10:2712. doi: 10.3389/fimmu.2019.02712

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Copyright © 2019 Donat, Thanei and Trendelenburg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CC-C1q-vWF complexes diminish LPS-induced IL-1 secretion of HMDMs. LPS-induced HMDMs were kept untreated or treated with CC, CC-C1q, or CC-C1q-vWF complexes for 18 h. Supernatants were analyzed by ELISA for cytokine secretion. Data show median cytokine concentrations of (A) IL-1β, (B) IL-1α, (C) IL-1RA, (F) IL-18, (G) IL-6, (H) IL-10, and (I) TNFα levels or median ratios of (D) IL-1β/IL-1RA and (E) IL-1α/IL-1RA of pooled donors. Data points represent independent experiments analyzing eight different healthy donors used to obtain HMDMs (Wilcoxon matched pairs signed rank test, *p < 0.05; **p < 0.01; ns, not significant).