Table 3.

Summary of the most-frequently administered QoL questionnaires in recurrent GB

Scale	EORTC QLQ-C30 [40]	Brain cancer module 20 (BCM20/BCN20) [41]	Functional assessment of Cancer Therapy–Brain (FACT-BR) [42]
Objective	To assess the QoL of patients with cancer	To be used in conjunction with the EORTC QLQ-C30 for measuring the health-related QoL in patients with brain cancer	To measure general QoL that reflects symptoms or problems associated with brain malignancies
Scoring scale used	Not at all: 1 A Little: 2 Quite a Bit: 3 Very Much: 4 Two global health status/QoL items are measured on a 7-point Likert scale (“very poor” to “excellent”)	Not at all: 1 A Little: 2 Quite a Bit: 3 Very Much: 4	Five-point Likert scale ranging from 0 "not at all" to 4 "very much"
Interpretation of results	Patient responses are scored on health-related QoL measurement scales according to standard algorithms All scales have a 0–100 range. Improvement in function is represented by an increase in score, whereas improvement in symptoms is represented by a decrease in score	Patient responses are scored on health-related QoL measurement scales according to standard algorithms All scales have a 0–100 range. Improvement in function is represented by an increase in score, whereas improvement in symptoms is represented by a decrease in score	Higher ratings suggest higher QoL. Items are totalled to produce a score for each subscore (physical well-being; social/family; emotional well-being; functional well-being; and concerns relevant to patients with brain tumours), plus an overall QoL score
Domains covered	Includes 30 questions that cover five aspects of functioning (physical, role, emotional, cognitive, social), eight symptoms (fatigue, pain, nausea/vomiting, dyspnoea, insomnia, appetite loss, constipation, diarrhoea), financial impact, and global health status/QoL	Includes 20 questions that cover future uncertainty, visual disorder, motor dysfunction, communication deficit, headache, seizures, drowsiness, hair loss, itching, difficulty with bladder control, and weakness of both legs	Includes 23 questions on aspects of physical well-being, social/family well-being, emotional well-being, functional well-being, and disease-specific concerns