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. 2019 Nov 21;11:320. doi: 10.3389/fnagi.2019.00320

FIGURE 3.

FIGURE 3

Minimal alteration of core clock operation in tau deficient flies. (A,B) Confocal images of LNv neurons immunostained for PDF, PER, and TIM, at different Zeitgeber times (ZT). Wholemount dissections of adult brains were done in control and dTau mutant of 7 day-old. (C) Quantification of PER, TIM, and PDF intensity levels across the indicated circadian time points (ZT-6, ZT-14, and ZT-22) shows significant increase in TIM and PER signals at ZT-14 when compared with controls. No changes were found at ZT-6 or ZT-22. Data represent mean and SEM analyzed by non-parametric Mann–Whitney statistical test (∗∗p < 0.01 and ∗∗∗p < 0.001; n = 12–14 hemispheres). Scale bar is 5 μm.