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. 2019 Nov 27;9:17639. doi: 10.1038/s41598-019-54065-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell death and DNA damage induction in normal and cancer lung cells after exposure to cisplatin. (A) A dose-response curve of three lung cell lines treated with increasing concentrations of cisplatin and analyzed after 72 h using the XTT assay. (B,C) The apoptotic fraction of lung cells treated with cisplatin for 72 h, analyzed as the sub-G1 population levels using flow cytometry of PI-stained nuclei or the fold increase of cells with active caspase-3 relative to control. (D) Flow cytometry analysis of γH2AX positive staining in lung cells upon treatment with cisplatin (5 μM) for 6 h and 24 h. Values are mean ± SEM of three independent experiments, *P < 0.05, **P < 0.01, ***P < 0.001.