Table 2.

Associations between changes in biomarkers and changes in other variables^a.

	Dependent variable
	C-reactive protein	Neopterin	Lactoferrin
Main multivariable models
Body mass index	0.22 (0.04–0.40) p = 0.016	−0.11 (−0.23, 0.02) p = 0.10	5.98 (−1.92, 13.88) p = 0.14
HbA1c	0.63 (−0.14, 1.39) p = 0.11	−0.05 (−0.38, 0.28) p = 0.76	−16.18 (−37.76, 5.40) p = 0.14
Sex	−1.62 (−3.23, −0.01) p = 0.048	0.48 (−0.95, 1.91) p = 0.51	−38.26 (−98.66, 22.14), p = 0.21
Age	−0.07 (−0.15, 0.00) p = 0.07	−0.02 (−0.06, 0.03) p = 0.48	0.23 (−3.80, 4.27) p = 0.91
Multivariable interaction modelsb
Body mass index * weight loss period
Body mass index * Conservative weight loss period Body mass index * Surgical weight loss period Overall interactionc	−0.17 (−0.44, 0.12), p = 0.27 –0.24 (−0.50, 0.02), p = 0.07 p = 0.12	−0.28 (−0.60, 0.04), p = 0.09 0.31 (−0.05, 0.67), p = 0.09 p = 0.21	−3.68 (−14.21, 6.86), p = 0.49 −1.14 (−10.78, 8.50), p = 0.82 p = 0.75
HbA1c * weight loss period
HbA1c * Conservative weight loss period HbA1c * Surgical weight loss period Overall interactionc	0.04 (−0.58, 0.67), p=0.90 0.45 (−0.78, 1.68), p=0.47 p = 0.70	−0.12 (−0.64, 0.40), p = 0.65 0.92 (−0.02, 1.85), p = 0.054 p = 0.11	−0.61 (−37.47, 36.25), p = 0.97 34.65 (−2.40, 71.71), p = 0.07 p = 0.18

^aCoefficients (95% CI) from multivariable mixed models.

^bCoefficients from similar multivariable mixed models including additional interaction term.

^cGives comparison of differences in associations between weight loss interventions.