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. 2019 Nov 27;9:17640. doi: 10.1038/s41598-019-54158-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Definition of Class I and II CFTR potentiators. (A) Chemical structures of Class I and II potentiators. (B) Short-circuit current in FRT cells expressing N1303K-CFTR in response to forskolin and indicated potentiators. Concentrations: 20 μM forskolin, 5 μM VX-770, 20 μM ASP-11, 20 μM GLPG1837, 20 μM P2, 20 μM P3, 20 μM P5, 20 μM W1282X_pot-C01, and 10 μM CFTR_inh-172. C. Short-circuit current in FRT cells expressing Q1313X-CFTR in response to forskolin and indicated potentiators. Concentrations: as in panel B, and 25 μM apigenin. (D) Summary of relative N1303K-CFTR activation in response to combinations of Class I and Class II potentiators. Mean ± S.E.M., n = 3.