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. 2019 Nov 27;9:17640. doi: 10.1038/s41598-019-54158-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Novel co-potentiators identified by high-throughput screening. (A) Assay design. (B) Summary of screening workflow and results. (C) Chemical structures of novel co-potentiators identified by screening. (D) Representative short-circuit current data in FRT cells expressing W1282X-CFTR. Concentrations: 20 μM forskolin (fsk), 5 μM VX-770 (n = 3). (E) Effects of sequential addition of 20 μM forskolin followed by 20 μM of A-01, B-01, C-01 and D-01, and 5 μM of VX-770 in FRT cells expressing W1282X-CFTR. CFTR_inh-172 was used at 10 μM in all experiments.