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. 2019 Nov 27;9:17640. doi: 10.1038/s41598-019-54158-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure-activity analysis of piperidine-pyridoindole and pyrazoloquinoline co-potentiators. (A) Structural determinants of piperidine-pyridoindole (CP-Axxx) and (B) pyrazoloquinoline (CP-Dxxx) co-potentiator activity. (C) Short-circuit current in FRT cells expressing N1303K-CFTR showing responses to 20 µM forskolin (fsk), 5 µM VX-770, and indicated concentrations of CP-A061 (left) and CP-D123 (center). (right) Summary of concentration-dependence data. (D) Short-circuit current in FRT cells expressing Q1313X-CFTR done as in panel C. (right) Summary of concentration-dependence data.