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. 2019 Nov 27;9:17640. doi: 10.1038/s41598-019-54158-2

Figure 6.

Figure 6

N1303K-CFTR activity in human airway epithelial cell cultures. (A) Short-circuit current in gene-edited 16HBE14o- cells expressing N1303K-CFTR. Concentrations: 20 µM amiloride, 20 µM forskolin, 5 µM VX-770, 20 µM CP-A061 and CP-D123, and 10 µM CFTRinh-172. Representative original curves (left and center) and summary of changes in current (∆Isc) (right). Mean ± S.E.M., n = 3, *P < 0.05). (B) Short-circuit current in primary cultures of human bronchial epithelial cells from a homozygous N1303K-CFTR CF subject. Concentrations were as in panel A. Representative original curves (left and center) and summary of changes in current (∆Isc) (right). Mean ± S.E.M., n = 3, *P < 0.05.