Table 4.
Sequence variants associated with PAD estimated using BOLT-LMM.
| rs Number (GRCh38) | Position (min/maj) | Allele | MAF () | Effect | 95% CI | P Value | |
|---|---|---|---|---|---|---|---|
| (A) | rs2435204 | chr17:45910839 | G/A | 26.6 | 0.11 | (0.08, 0.14) | 1.4e−12 |
| rs1452628 | chr1:214966544 | T/A | 36.2 | −0.08 | (−0.10, −0.05) | 2.3e−09 | |
| (B) | rs2790099 | chr6:45475612 | C/T | 36.0 | −0.06 | (−0.09, −0.03) | 8.9e−06 |
| rs6437412 | chr3:194747684 | C/T | 28.2 | −0.06 | (−0.09, −0.04) | 6.8e−06 | |
| rs2184968 | chr6:126439848 | C/T | 46.0 | 0.05 | (0.03, 0.08) | 7.5e−05 | |
| (C) | rs2435204 | chr17:45910839 | G/A | 26.6 | 0.08 | (0.03, 0.13) | 1.5e−03 |
| rs1452628 | chr1:214966544 | T/A | 36.2 | −0.07 | (−0.12, −0.03) | 8.8e−04 | |
| (D) | rs2790099 | chr6:45475612 | C/T | 36.0 | −0.07 | (−0.11, −0.02) | 2.9e−03 |
| rs6437412 | chr3:194747684 | C/T | 28.2 | −0.05 | (−0.09, 0.00) | 4.9e−02 | |
| rs2184968 | chr6:126439848 | C/T | 46.0 | 0.06 | (0.02, 0.10) | 2.9e−03 |
(A, B) Association between sequence variants and PAD for 12378 subjects in discovery set. (A) Genome-wide significant sequence variants. (B) Sequence variants associated with structural MRI brain phenotypes that also associate with PAD. (C, D) Association between sequence variants and PAD for 4456 subjects from the replication set. (C) Genome-wide significant sequence variants. (D) Sequence variants associated with structural MRI brain phenotypes that also associate with PAD. Note that the reported effect sizes are for PAD normalized to unit variance. Before normalization the standard deviation of PAD was ~4 years. Thus the associated lowering of the protective allele of rs1452628 is approximately −0.32 years
CI confidence interval, MAF minor allele frequency